Spectral Profiling of Early αsyn Aggregation in HEK293 Cells Modified to Stably Express Human WT and A53T-αsyn. [PDF]
CellsAlpha-synuclein (αsyn) misfolding and aggregation underlie several neurodegenerative disorders, including Parkinson’s disease. Early oligomeric intermediates are particularly toxic yet remain challenging to detect and characterize within cellular systems.
Swaminathan P +7 more
europepmc +2 more sources
Comparing the cytotoxic effects of iron oxide nanoparticles synthesized using the cytoplasmic extract of Lactobacillus casei and chemical synthesis [PDF]
Medical Laboratory Journal, 2023 Background: Discovering new cytotoxic compounds has received significant attention due to the rise in drug resistance and the adverse effects associated with chemotherapy drugs.
mahnoosh fatemi +3 more
doaj
Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α. [PDF]
PLoS ONE, 2011 Helicobacter pylori is the causative agent for developing gastritis, gastric ulcer, and even gastric cancer. Virulent strains carry the cag pathogenicity island (cagPAI) encoding a type-IV secretion system (T4SS) for injecting the CagA protein.
Suneesh Kumar Pachathundikandi +3 more
doaj +1 more source
Effect of Quercetin on Injury to Indomethacin-Treated Human Embryonic Kidney 293 Cells
Life, 2021 Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat inflammation and pain and even to prevent the progression of cardiovascular disease. They have become widely used because of their effectiveness, especially among athletes performing high ...
Chun Chen +4 more
doaj +1 more source
Human concentrative nucleoside transporter 3 transfection with ultrasound and microbubbles in nucleoside transport deficient HEK293 cells greatly increases gemcitabine uptake. [PDF]
PLoS ONE, 2013 Gemcitabine is a hydrophilic clinical anticancer drug that requires nucleoside transporters to cross plasma membranes and enter cells. Pancreatic adenocarcinomas with low levels of nucleoside transporters are generally resistant to gemcitabine and are ...
Robert J Paproski +6 more
doaj +1 more source
Acta Virologica, 2023 Human adenovirus-5 (hAd5) is an important gene delivery vector, which has been widely used in various fields of biomedicine, such as gene therapy, cancer therapy, and vaccine development.
Wenbo Xie +4 more
doaj +1 more source
Characterization of amiodarone action on currents in hERG-T618 gain-of-function mutations
Open Life Sciences, 2023 Ami (10 μM) had a greater retarding effect on the hERG-T618I channel than WT (P < 0.05). The half-inhibitory concentration for the mutant (4.56 μM) was approximately 1.82 times that of WT (2.51 μM).
Lin Min +5 more
doaj +1 more source
Drug Delivery, 2023 Extracellular vesicles (EVs) are lipid membrane-bound particles involved in cell-to-cell communication through a delivery of regulatory molecules essential for physiological processes.
Stefania Zuppone +2 more
doaj +1 more source
Inhibitory Effect of CCK-8 on Methamphetamine-Induced Apoptosis
Fayixue Zazhi, 2021 ObjectiveTo investigate the inhibitory effect of cholecystokinin octapeptide （CCK-8） binding to cholecystokinin 2 receptor （CCK2R） on methamphetamine （METH）-induced neuronal apoptosis, and to explore the signal transduction mechanism of β-arrestin 2 in ...
ZHANG Wu-hua +8 more
doaj +1 more source
Toxins, 2021 Patulin (PAT) belongs to the family of food-borne mycotoxins. Our previous studies revealed that PAT caused cytotoxicity in human embryonic kidney cells (HEK293).
Jiayu Liu +8 more
doaj +1 more source