Results 31 to 40 of about 150,776 (304)

6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist

Biomolecules, 2022
P2X7 is an extracellular adenosine 5′-triphopshate (ATP)-gated cation channel present on leukocytes, where its activation induces pro-inflammatory cytokine release and ectodomain shedding of cell surface molecules.
Peter Cuthbertson, Amal Elhage, Dena Al-Rifai, Reece A. Sophocleous, Ross J. Turner, Ashraf Aboelela, Hiwa Majed, Richard S. Bujaroski, Iman Jalilian, Michael J. Kelso, Debbie Watson, Benjamin J. Buckley, Ronald Sluyter   +12 more
doaj   +1 more source

HEK293S Cells Have Functional Retinoid Processing Machinery [PDF]

The Journal of General Physiology, 2002
Rhodopsin activation is measured by the early receptor current (ERC), a conformation-associated charge motion, in human embryonic kidney cells (HEK293S) expressing opsins. After rhodopsin bleaching in cells loaded with 11-cis-retinal, ERC signals recover in minutes and recurrently over a period of hours by simple dark adaptation, with no added ...
Brueggemann, Lioubov I., Sullivan, Jack M.   +1 more
openaire   +2 more sources

Expression of heterologous oxalate decarboxylase in HEK293 cells confers protection against oxalate induced oxidative stress as a therapeutic approach for calcium oxalate stone disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Oxalates stimulate alterations in renal epithelial cells and thereby induce calcium oxalate (CaOx) stone formation. Bacillus subtilis YvrK gene encodes for oxalate decarboxylase (OxdC) which degrades oxalate to formate and CO2.
Abhishek Albert, Vidhi Tiwari, Eldho Paul, Divya Ganesan, Mahesh Ayyavu, Ritu Kujur, Sasikumar Ponnusamy, Kathiresan Shanmugam, Luciano Saso, Selvam Govindan Sadasivam   +9 more
doaj   +1 more source

Automation of large scale transient protein expression in mammalian cells [PDF]

, 2011
Traditional mammalian expression systems rely on the time-consuming generation of stable cell lines; this is difficult to accommodate within a modern structural biology pipeline.
Susan Daenke, Jones, M, E. Yvonne Jones, Siebold, Christian, Daenke, Susan, Christian Siebold, Bishop, Benjamin, Margaret Jones, Clay, Jordan E, Stuart, David I., A. Radu Aricescu, Zhao, Y, Benjamin Bishop, Aricescu, Alexandru R, Radu Aricescu, A, Stuart, David, Yvonne Jones, E, Weixian Lu, Stuart, David I, Clay, JE, Daenke, S, Aricescu, Alexandru, Bishop, B, Jones, EY, Clay, Jordan E., Yuguang Zhao, Jones, Margaret, Lu, Weixian, David I. Stuart, Radu Aricescu, A., Yvonne Jones, E., Aricescu, AR, Jones, Edith, Jordan E. Clay, Zhao, Yuguang, Jones, E Yvonne, Lu, W, Siebold, C, Stuart, DI   +38 more
core   +1 more source

Biological characterization of HEK293-C34 cells and SARS-CoV-2.

, 2023
(A) Growth kinetics of HEK293-C34 cells. HEK293-C34 cells were counted for 48 hours after seeding. (B) Degradation rate of SARS-CoV-2. Virus titers were determined every 12 hours during incubation at 37°C. (PPTX)
Shiho Torii (12770667), Yong Dam Jeong (14846302), Kei Sato (493447), Rigel Suzuki (12770673), Kwang Su Kim (1960972), Jumpei Ito (761675), Hiroyuki Asakura (1617940), Teppei Shimamura (133856), Takasuke Fukuhara (673475), Yasuhisa Fujita (10344689), Shoya Iwanami (3945266), Kazuhisa Yoshimura (322429), Kenji Sadamasu (7438220), Jun Koseki (738263), Yoshiharu Matsuura (357989), Shingo Iwami (266092), Mami Nagashima (14846305)   +16 more
core   +1 more source

A cell function study on calcium regulation of a novel calcium-sensing receptor mutation (p.Tyr825Phe) [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2021
Purpose Autosomal dominant hypocalcemia with hypercalciuria is a genetic disease characterized by hypoparathyroidism with hypercalciuria. We discovered a novel variant (p.Tyr825Phe[Y825F]) of the CASR gene in a neonate with congenital hypoparathyroidism ...
Jung Eun Moon, Hee-Young Yang, Gabbine Wee, Suk-Hyun ParK, Cheol Woo Ko   +4 more
doaj   +1 more source

A cell model to study different degrees of Hsp60 deficiency in HEK293 cells [PDF]

Cell Stress and Chaperones, 2011
Mitochondrial dysfunction is associated with neurodegenerative diseases and mutations in the HSPD1 gene, encoding the mitochondrial Hsp60 chaperone, are the causative factors of two neurodegenerative diseases, hereditary spastic paraplegia and MitChap60 disease.
Bie, Anne Sigaard, Palmfeldt, Johan, Hansen, Jakob, Christensen, Rikke, Gregersen, Niels, Corydon, Thomas Juhl; id_orcid 0000-0003-3588-6350, Bross, Peter; id_orcid 0000-0001-9526-8525   +6 more
openaire   +3 more sources

MicroRNAs regulate "de novo" DNA methylation and histone mRNA 3' end formation in mammalian cells [PDF]

, 2008
MicroRNAs (miRNAs) are known to have many important functions in mammalian cells. They can influence the expression of their target genes and in this way regulate the function of not only their primary targets, but also of the pathways and mechanisms ...
Sinkkonen, Lasse
core   +1 more source

Circular RNA-0007059 protects cell viability and reduces inflammation in a nephritis cell model by inhibiting microRNA-1278/SHP-1/STAT3 signaling

Molecular Medicine, 2021
Background Increasing evidence has indicated that circular RNAs (circRNAs) play a role in various diseases. However, the influence of circRNAs in nephritis remains unknown.
Peng-Wei Guo, Hai-Ting Huang, Jing Ma, Yao Zuo, Dan Huang, Lin-Lin He, Zi-Ming Wan, Cheng Chen, Fa-Fen Yang, Yan-Wu You   +9 more
doaj   +1 more source

Emerging role of calcium-activated potassium channel in the regulation of cell viability following potassium ions challenge in HEK293 cells and pharmacological modulation.

PLoS ONE, 2013
Emerging evidences suggest that Ca(2+)activated-K(+)-(BK) channel is involved in the regulation of cell viability. The changes of the cell viability observed under hyperkalemia (15 mEq/L) or hypokalemia (0.55 mEq/L) conditions were investigated in HEK293
Domenico Tricarico, Antonietta Mele, Sara Calzolaro, Gianluigi Cannone, Giulia Maria Camerino, Maria Maddalena Dinardo, Ramon Latorre, Diana Conte Camerino   +7 more
doaj   +1 more source