Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells [PDF]
, 2005 Type 2 hereditary hemochromatosis (HH) or juvenile hemochromatosis is an early onset, genetically heterogeneous, autosomal recessive disorder of iron overload.
Bjorkman, Pamela J. +4 more
core +1 more source
Cell engineering for the production of hybrid-type N-glycans in HEK293 cells
The Journal of Biochemistry, 2021 Abstract Glycoprotein therapeutics are among the leading products in the biopharmaceutical industry. The heterogeneity of glycans in therapeutic proteins is an issue for maintaining quality, activity and safety during bioprocessing. In this study, we knocked out genes encoding Golgi α-mannosidase-II, MAN2A1 and MAN2A2 in human embryonic ...
Ji-Xiong Leng +5 more
openaire +2 more sources
Journal of Pharmacological Sciences, 2022 OAT10 (SLC22A13) is a transporter highly expressed in renal tubules and transporting organic anions including nicotinate, β-hydroxybutyrate, p-aminohippurate, and orotate. In transport assays using Xenopus oocytes and HEK293 cells, we found that apparent
Naoko Ohtsu +9 more
doaj +1 more source
Catechol estrogens stimulate insulin secretion in pancreatic β-cells via activation of the transient receptor potential A1 (TRPA1) channel [PDF]
, 2019 Estrogen hormones play an important role in controlling glucose homeostasis and pancreatic β-cell function. Despite the significance of estrogen hormones for regulation of glucose metabolism, little is known about the roles of endogenous estrogen ...
Cabrera, Over +7 more
core +1 more source
6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist
Biomolecules, 2022 P2X7 is an extracellular adenosine 5′-triphopshate (ATP)-gated cation channel present on leukocytes, where its activation induces pro-inflammatory cytokine release and ectodomain shedding of cell surface molecules.
Peter Cuthbertson +12 more
doaj +1 more source
HEK293S Cells Have Functional Retinoid Processing Machinery [PDF]
The Journal of General Physiology, 2002 Rhodopsin activation is measured by the early receptor current (ERC), a conformation-associated charge motion, in human embryonic kidney cells (HEK293S) expressing opsins. After rhodopsin bleaching in cells loaded with 11-cis-retinal, ERC signals recover in minutes and recurrently over a period of hours by simple dark adaptation, with no added ...
Brueggemann, Lioubov I. +1 more
openaire +2 more sources
Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2 and cell proliferation via Gαq-mediated mechanism [PDF]
, 2014 Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Bai, B +5 more
core +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 Oxalates stimulate alterations in renal epithelial cells and thereby induce calcium oxalate (CaOx) stone formation. Bacillus subtilis YvrK gene encodes for oxalate decarboxylase (OxdC) which degrades oxalate to formate and CO2.
Abhishek Albert +9 more
doaj +1 more source
A cell function study on calcium regulation of a novel calcium-sensing receptor mutation (p.Tyr825Phe) [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2021 Purpose Autosomal dominant hypocalcemia with hypercalciuria is a genetic disease characterized by hypoparathyroidism with hypercalciuria. We discovered a novel variant (p.Tyr825Phe[Y825F]) of the CASR gene in a neonate with congenital hypoparathyroidism ...
Jung Eun Moon +4 more
doaj +1 more source
Lack of evidence for decreased protein stability in the 2397 (Met) haplotype of the leucine rich repeat kinase 2 protein implicated in Parkinson’s disease [PDF]
, 2017 Missense mutations in the leucine rich repeat kinase 2 (LRRK2) gene are the leading genetic cause of autosomal dominant familial Parkinson’s disease.
Anderton, Ryan S +5 more
core +2 more sources