Results 111 to 120 of about 449,069 (245)

The Gold‐Maker of Animal Oil and Prussian Blue Fame — The Chemical and Medicinal Science Philosophy of Johann Conrad Dippel

The Chemical Record, EarlyView.
The radical Pietist Johann Conrad Dippel was a self‐proclaimed adept – a maker of gold and the philosophers’ stone. He was also a magister of theology, a doctor of medicine, and a self‐taught chemist, who coinvented the pigment Prussian Blue together with Johann von Diesbach, became known for his animal pyrolysis oil, his wonder‐wound balm, his ...
Curt Wentrup
wiley   +1 more source

Curcumin attenuates collagen-induced inflammatory response through the “gut-brain axis”

Journal of Neuroinflammation, 2018
Background Previous studies have demonstrated that oral administration of curcumin exhibited an anti-arthritic effect despite its poor bioavailability. The present study aimed to explore whether the gut-brain axis is involved in the therapeutic effect of
Yannong Dou, Jinque Luo, Xin Wu, Zhifeng Wei, Bei Tong, Juntao Yu, Ting Wang, Xinyu Zhang, Yan Yang, Xusheng Yuan, Peng Zhao, Yufeng Xia, Huijuan Hu, Yue Dai   +13 more
doaj   +1 more source

Resin‐coated urea effectively simulates the chronic dynamics of natural nitrogen deposition

Methods in Ecology and Evolution, EarlyView.
Abstract Atmospheric nitrogen (N) deposition has more than tripled globally since the Industrial Revolution. Experiments usually simulate N deposition using fast‐release N fertilizers applied once or several times a year. However, these pulses differ from the continuous N supply of natural deposition, which may lead to different outcomes.
Yi Zhao, Yuguang Ke, Honghui Wu, Chong Xu, Xiwen Li, Yann Hautier, Elizabeth T. Borer, Qiang Yu   +7 more
wiley   +1 more source

Identifying ENO1 as a protein target of chlorogenic acid to inhibit cellular senescence and prevent skin photoaging in mice

Aging Cell, Volume 24, Issue 4, April 2025.
A schematic depiction of chlorogenic acid inhibited UVA‐induced cellular senescence and mouse skin photoaging by suppressing the activity of Enolase 1 (ENO1) protein to block glycolytic pathway. Abstract Cellular senescence plays a critical role in repeated ultraviolet (UV) exposure‐induced skin photoaging. Currently, from the perspective of regulating
Xueling He, Chen Wang, Qianyu Zhang, Tong Yang, Qiuyan Guo, Yaxu Wang, Jiayue Guo, Pengjie Wang, Junzhe Zhang, Huan Tang, Yinhua Zhu, Jigang Wang   +11 more
wiley   +1 more source

Integrating network pharmacology and animal experimental validation to investigate the action mechanism of oleanolic acid in obesity

Journal of Translational Medicine
Background Obesity, a condition associated with the development of widespread cardiovascular disease, metabolic disorders, and other health complications, has emerged as a significant global health issue.
Tianfeng Liu, Jiliang Wang, Ying Tong, Lele Wu, Ying Xie, Ping He, Shujue Lin, Xuguang Hu   +7 more
doaj   +1 more source

SQSTM1/p62 Orchestrates Skin Aging via USP7 Degradation

Aging Cell, EarlyView.
p62 exhibits diminished expression in aging skin and senescent cells. p62 serves to inhibit the accumulation of USP7 during senescence induction. The Tyr‐67 residue within the PB1 domain or Gln‐418 within the UBA domain of p62 forms a hydrogen bond with Ala‐993 of the Ubl5 domain of USP7.
Liu Chen, Xiaoping Wang, Yuchen Wang, Qingxin Yao, Yunyao Liu, Yongcheng Zhu, He Huang, Hedan Yang, Yin Yang, Yuan He, Lei Qiang   +10 more
wiley   +1 more source

Discovery of novel coumarin derivatives as potent and orally bioavailable BRD4 inhibitors based on scaffold hopping

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The bromodomain and extra-terminal (BET) bromodomains, particularly BRD4, have been identified as promising therapeutic targets in the treatment of many human disorders such as cancer, inflammation, obesity, and cardiovascular disease.
Zhimin Zhang, Lili Gu, Beibei Wang, Wenhai Huang, Yanmin Zhang, Zhen Ma, Shenxin Zeng, Zhengrong Shen   +7 more
doaj   +1 more source

Lipidomics coupled with pathway analysis characterizes serum metabolic changes in response to potassium oxonate induced hyperuricemic rats

Lipids in Health and Disease, 2019
Background Hyperuricemia as a metabolic disease is usually associated with lipid metabolic disorder. The purpose of this study is to identify potential lipid biomarkers and provide the evidence for the relationship between hyperuricemia and lipid-related
Fei Yang, Mingyu Liu, Nankun Qin, Shuangshuang Li, Mengqi Yu, Chengxiang Wang, Qun Ma   +6 more
doaj   +1 more source

Museum of Materia Medica(Research Center for Ethnomedicine) [PDF]

, 2006
この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されまし
出口 鳴美, 小松 かつ子
core   +1 more source

Involvement of Piezo 1 in inhibition of shear‐induced platelet activation and arterial thrombosis by ginsenoside Rb1

British Journal of Pharmacology, Volume 182, Issue 9, Page 1957-1974, May 2025.
Abstract Background and Purpose Shear‐induced platelet activation and aggregation (SIPA) play crucial roles in arterial thrombosis. Piezo1 is a mechanosensitive calcium channel that promotes platelet hyperactivation under pathological high‐shear conditions.
Yilin Wang, Lu Liu, Jia Li, Yue You, Shunli Xiao, Jiantao Feng, Xiaojie Yin, Fulong Liao, Yun You   +8 more
wiley   +1 more source