Results 61 to 70 of about 510,925 (311)
Purpose Maytansine (DM1) is a potent anticancer drug and limited in clinical application due to its poor water solubility and toxic side effects. Zein is widely used in nano drug delivery systems due to its good biocompatibility.
Xianglong Yu +8 more
doaj +1 more source
Museum of Materia Medica(Research Center for Ethnomedicine) [PDF]
この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されまし
出口 鳴美, 小松 かつ子
core +1 more source
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang +11 more
wiley +1 more source
The aim of this study was to evaluate the effects of crude extract of Eupatorium lindleyanum DC. (CEEL) on reducing hyperlipidemia and preventing atherosclerosis induced with a high cholesterol diet (HCD) in rabbits.
Xing Zhou +6 more
doaj +1 more source
Lilium pumilum DC. is a useful plant species not only for its showy flowers but also for its edible and medicinal values. Here we report on the complete chloroplast genome sequence of L. pumilum.
Jian Jin +8 more
doaj +1 more source
Lichens Mentioned by Pedanios Dioscorides [PDF]
Lichens are included in the classification system of fungi and have been used in medicine, pharmacy and industry from antiquity to present day in the treatment of various diseases.
Yavuz, Mustafa
core
Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen +19 more
wiley +1 more source
Arachidonic acid (AA) signaling pathway is an important constituent of inflammatory processes. In our previous study, it was found that dihydro-stilbene gigantol relieved hepatic inflammation in mice with CCl4-induced acute liver injury. This study aimed
Yaru Xue +10 more
doaj +1 more source
Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li +17 more
wiley +1 more source
Preclinical and clinical studies of medical preparations (rengalin, ergoferon) containing release-active (P-A) antibodies to histamine confirmed their ability to provide anti-inflammatory and anti-allergic effect.
E. S. Zhavbert +2 more
doaj +1 more source

