Results 91 to 100 of about 3,945,168 (273)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Service evaluation to establish the sensitivity, specificity and additional value of broad-range 16S rDNA PCR for the diagnosis of infective endocarditis from resected endocardial material in patients from eight UK and Ireland hospitals [PDF]

, 2014
Infective endocarditis (IE) can be diagnosed in the clinical microbiology laboratory by culturing explanted heart valve material. We present a service evaluation that examines the sensitivity and specificity of a broad-range 16S rDNA polymerase chain ...
Alshafi, K, Gouliouris, T, Harris, KA, Hartley, JC, Jalili, S, Munthali, P, NiRiain, U, Williams, OM, Yam, T   +8 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Material Culture and Structural Violence: Reframing Evidence of the Social Gradient in Industrial Contexts. [PDF]

Hist Archaeol, 2022
Cools K.
europepmc   +1 more source

Relevance, Resonance, and Historiography: Interpreting the Lives and Experiences of Civil War Soldiers

, 2016
Carmichael shares his experiences of portraying Corporal Bobby Fields at Appomattox Court House National Historical Park in the summer of 1985. He uses Fields as a conduit to explore the scholarship pertaining to the common soldier of the Civil War and ...
Carmichael, Peter S.
core   +1 more source

Status, taste and distinction in consumer culture: acknowledging the symbolic dimensions of inequality [PDF]

, 2008
The relationship between social position and health has been the focus of extensive public health debate. In the UK and elsewhere, most researchers have focused on physical aspects of health, using indicators such as mortality and morbidity to draw a ...
Archer, Bartley, Bauman, Black, Bourdieu, Charlesworth, Davey Smith, Davey Smith, Eckersley, Eckersley, Featherstone, Featherstone, Freire, Frolich, Giddens, Gould, Hartmut, Krieger, Lupton, Lury, Marcus, Margaret Hannah, Marmot, Marmot, Marmot, McLeod, McLeod, Miller, Nesse, Phil Hanlon, Ransome, Sandra Carlisle, Scambler, Shilling, Slater, Sointu, Sullivan, Townsend, Wallerstein, Wilkinson, Wilkinson, Wilkinson, Wilkinson, Wilkinson, Wilkinson, Williams, Williams   +46 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Historical Epistemology Meets the Human Sciences [PDF]

, 2011
The paper addresses recent developments in historical epistemology, traces the main inspirational sources that feed this approach, and suggests a possible agenda for closer approximation between historical epistemology and the human sciences in studying ...
Balon, Jan, Dvořák, Tomáš
core  

Characterisation and textural analysis of Middle Bronze Age Transdanubian inlaid wares of the Encrusted Pottery Culture, Hungary: a preliminary study

, 2008
Inlaid ceramics belonging to the Encrusted Pottery Culture and dated to the Middle Bronze Age (2000–1500 BC) are highly distinctive vessels with complex decorative motifs found in large numbers in the Transdanubia region of Hungary.
Kiss, V., Roberts, S., Sofaer, J.
core   +1 more source