Results 111 to 120 of about 3,945,168 (273)

Additional Material Culture Remains from the Bowles Creek Site (41CE475) in Cherokee County, Texas [PDF]

open access: yes, 2016
The Bowles Creek site is on a low alluvial rise in the Bowles Creek floodplain; Bowles Creek is a southward-flowing tributary of the Neches River. Stingley found the site in early 2015 during a surface walk over, when Caddo ceramic sherds were noted in a
Perttula, Timothy K., Stingley, Kevin
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

THE EARLIEST EVIDENCE OF THE MANUFACTURING OF SOLUTIONS AND VISCOPLASTIC MIXTURES FROM PAINT PIGMENTS ON THE RUSSIAN PLAIN IN THE MIDDLE PALEOLITHIC

open access: yesНижневолжский археологический вестник
The article presents the results of studying a series of small individual pigment particles discovered in the cultural layer of the Chelyuskinets II site, which is part of the Lower Volga Middle Paleolithic group together with the Eurasian ...
Maria Zheltova   +12 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Yakov A. Sher (1931–2019): Milestones of Academic Career

open access: yesСибСкрипт
Professor Yakov A. Sher (1931–2019), Doctor of History, was a world-famous specialist in prehistoric art. This research relied on the archives of the Institute for Material Culture History, the State Hermitage Museum, and the Kemerovo State University to
Lyudmila Yu. Kitova   +2 more
doaj   +1 more source

Pedagogies of Race: The Politics of Whiteness in an African American Studies Course [PDF]

open access: yes, 2011
This paper evaluates students\u27 arguments for a color-blind society to avoid discussions related to the continued existence of racism in USA culture.
Jones, Regina V.
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Clan Crypts on the Lower Don of the Early Catacomb Time and Genesis Issues of the Catacomb Rite

open access: yesНижневолжский археологический вестник
The article provides comprehensive information about two Middle Bronze Age burials (No. 26, 42) from the kurgan 1 in the burial mound Vesely I near Novocherkassk in the Rostov region. The burials contained double tombs with a complex rite and prestigious
Alexey V. Kiyashko
doaj   +1 more source

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