Results 41 to 50 of about 1,336,966 (305)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The long and winding road

Documenta Praehistorica
In this paper we address the biography of a set of copper nails recovered in 1998 from a Late Iron Age structure located at the archaeological site of Puig de Sa Morisca (Mallorca, Spain).
Laura Perelló Mateo, Bartomeu Llull Estarellas, Daniel Albero Santacreu, Jaume García Rosselló, Manuel Calvo Trias   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Mierzanowice culture material from Spišský hrad

, 2023
The Spiš Castle (Spišský hrad) hill (632 a.s.l.) is located administratively within the village of Žehra, Spišská Nová Ves district, the northern part of eastern Slovakia, in the historic region of Spiš.
Stejskal, Martin, Marta Kučerová, Paweł Madej, Martin Stejskal, Kučerová, Marta, Madej, Paweł   +5 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Parasites provide evidence for fish consumption among Iron Age Siberian pastoralists

Scientific Reports
The subsistence economies of prehistoric pastoralists of the Eurasian steppes have long been viewed through an oversimplified model of reliance on domesticated animals.
Sergey Slepchenko, Timur Sadykov, Daria Fomicheva, Jegor Blochin, Gino Caspari   +4 more
doaj   +1 more source

An experience of application of experimental-traceological analysis to ethnographic collections (the example of the ulu-knife of the Alutiiq Eskimos from Kodiak Island) [PDF]

Вестник археологии, антропологии и этнографии
The article presents the results of a comprehensive analysis of an ulu-knife (uluchik) from the ethnographic collection of I.G. Voznesensky of the Alutiiq Eskimos from the island of Kodiak (MAE No. 593-44).
Terekhina V.V.
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Unravelling the construction of silver filigree spheres from a seventeenth century shipwreck using non-invasive imaging

Heritage Science, 2022
The structure of five rare filigree spheres from a seventeenth century shipwreck was examined in order to unravel their condition, manufacturing process and function.
Janneke van der Stok-Nienhuis, Tonny Beentjes, Dominique Ngan-Tillard, Lambert van Eijck, Ineke Joosten, Maarten R. van Bommel   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source