Results 61 to 70 of about 2,815,885 (243)
A Monolithically Fabricated Combinatorial Mixer for Microchip-Based High-Throughput Cell Culturing Assays [PDF]
, 2007 We present an integrated method to fabricate 3- D microfluidic networks and fabricated the first on-chip cell culture device with an integrated combinatorial mixer.
Ho, Dean, Liu, Mike C., Tai, Yu-Chong
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Editors’ Introduction: Approaching the online audience: new practices, new thinking [PDF]
, 2011 Convergence culture, participatory culture, user generated content, interactive media; these are all now familiar terms within contemporary media and communication studies that have risen to distinguish emergent content across digital platforms and ...
Athique, Adrian M. +3 more
core +1 more source
Khirbet al-Batrawy ceramics. A systematic mineralogical and petrographic study for investigating the material culture [PDF]
, 2017 The present paper reports the results of a mineralogical and petrographic study focused on the archaeometric characterization of Early Bronze Age pottery from the archaeological site of Khirbet al-Batrawy (Jordan), dated between 3000 and 2000 BC. Optical
Medeghini, Laura, Nigro, Lorenzo
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The rise of Novgorod revisited
Slavia Antiqua, 2019 This article deals with the problem of the cultural, political and ethnic characteristics of the first settlers of Novgorod. The previous historiography is critically reviewed.
Aleksandr Musin
doaj
, 2013 All original material in this collection is distributed under a Free Culture license. You are free to share, remix, and make commercial use of the work, under the Attribution and Share Alike ...
Torroni, Paolo
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Поволжская археологияThe Mesolithic population inhabiting the Eastern European Forest zone demonstrated remarkable skill in processing bone raw materials and crafting a diverse array of implements for both strategic and domestic purposes.
Lozovskaya Olga +2 more
doaj +1 more source