Results 61 to 70 of about 1,198,346 (259)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

The rise of Novgorod revisited

open access: yesSlavia Antiqua, 2019
This article deals with the problem of the cultural, political and ethnic characteristics of the first settlers of Novgorod. The previous historiography is critically reviewed.
Aleksandr Musin
doaj  

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Technological Traces on Bone Artefacts from the Late Mesolithic Forest Zone: an attempt at generalization and interpretation (case study of the site Zamostje 2)

open access: yesПоволжская археология
The Mesolithic population inhabiting the Eastern European Forest zone demonstrated remarkable skill in processing bone raw materials and crafting a diverse array of implements for both strategic and domestic purposes.
Lozovskaya Olga   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Hide-Scrapers from Arukhlo I Settlement in Georgia (on correspondence of the shape and function of prehistoric implements)

open access: yesПоволжская археология, 2017
The article analyses one of the primary categories of the implement complex discovered at Arukhlo I Neolithic settlement (Georgia, Kvemo Kartli Region). The stone implements discovered at the site are characterized by their great variety.
Esakia Ketevan M.   +2 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

New Data on the Middle Paleolithic Site Chelyuskinets II (Based on 2024 Fieldwork Results)

open access: yesНижневолжский археологический вестник
The article presents the results of field work of the Lower Volga Paleolithic Expedition of the Institute of Archaeology and Ethnography of the Russian Academy of Sciences, Siberian Branch, organized within the framework of the integrated Lower Volga ...
Aleksander K. Otcherednoy   +6 more
doaj   +1 more source

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