Results 51 to 60 of about 3,945,168 (273)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Balancing Acts Between Ancient and Modern Cities: The Ancient Greek Cities Project of C. A. Doxiadis
Architectural Histories, 2015 This paper examines the inception and development of the Ancient Greek Cities (AGC) research project (1963–77) of Constantinos A. Doxiadis and addresses the novelty of its methodological approach to the study of classical urbanism.
Mantha Zarmakoupi
doaj +1 more source
An analysis of culture as a tourism commodity [PDF]
, 2009 The notion of culture has been the object of multidisciplinary studies attempting, with difficulty, to define this polyhedral social concept expressed in symbolic representations.
Maccarrone-Eaglen, A
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Changing Practice in a National Legal Deposit Library [PDF]
, 2006 This two-part essay considers how digital culture has influenced ideas about permanence and looks at the change in collecting practice in a legal deposit library.
Mason, Ingrid
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Open Archaeology, 2023 Psychoacoustics offers a promising, subject-centred approach in unlocking the sonic experience of past built spaces. Its tools and metrics offer tempting responses to an essential challenge of sensory archaeology practice: the rendition of individual ...
Jordan Pamela
doaj +1 more source
Metaphor and Materiality in Early Prehistory [PDF]
, 2010 In this paper we argue for a relational perspective based on metaphorical rather than semiotic understandings of human and hominin1 material culture. The corporeality of material culture and thus its role as solid metaphors for a shared experience of ...
Coward, Fiona, Gamble, C.
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
An experience of application of experimental-traceological analysis to ethnographic collections (the example of the ulu-knife of the Alutiiq Eskimos from Kodiak Island) [PDF]
Вестник археологии, антропологии и этнографииThe article presents the results of a comprehensive analysis of an ulu-knife (uluchik) from the ethnographic collection of I.G. Voznesensky of the Alutiiq Eskimos from the island of Kodiak (MAE No. 593-44).
Terekhina V.V.
doaj +1 more source