Results 61 to 70 of about 3,960,500 (346)

Changing Practice in a National Legal Deposit Library [PDF]

, 2006
This two-part essay considers how digital culture has influenced ideas about permanence and looks at the change in collecting practice in a legal deposit library.
Mason, Ingrid
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Metaphor and Materiality in Early Prehistory [PDF]

, 2010
In this paper we argue for a relational perspective based on metaphorical rather than semiotic understandings of human and hominin1 material culture. The corporeality of material culture and thus its role as solid metaphors for a shared experience of ...
Coward, Fiona, Gamble, C.
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Microbial population dynamics in rubber coagula from Hevea brasiliensis [PDF]

, 2013
Natural rubber produced from the tree Hevea brasiliensis is a material of first importance for the tyre industry and for many other sectors such as the vibration isolation and the general rubber good industries. To produce TSR10 or 20 block rubber, trees
Bonfils, Frédéric, Dubreucq, Eric, Granet, Françoise, Intapun, Jutharat, Sainte-Beuve, Jérôme, Salomez, M., Santoni, Sylvain, Subileau, Maeva, Vaysse, Laurent   +8 more
core  

Lessons from Love-Locks: The archaeology of a contemporary assemblage [PDF]

, 2017
This document is the Accepted Manuscript version. The final, definitive version of this paper has been published in Journal of Material Culture, November 2017, published by SAGE Publishing, All rights reserved.Loss of context is a challenge, if not the ...
Bord J, Bradley R, Brück J, Ceri Houlbrook, Day JW, Douglas M, Dowden K, Fontijn DR, Gell A, Gruner E, Hammond CI, Houlbrook C, Houlbrook C, Jones A, Kalshoven PT, Laing LR, Lavrinec J, Leins I, Leins I, MacDowall L, Maiwald K, Mason R, Merrifield R, Miller D, Pietrobruno S, Priest V, Richards C, Score V, Score V, Stead IM, Thompson M, Williams J   +31 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Editors’ Introduction: Approaching the online audience: new practices, new thinking [PDF]

, 2011
Convergence culture, participatory culture, user generated content, interactive media; these are all now familiar terms within contemporary media and communication studies that have risen to distinguish emergent content across digital platforms and ...
Athique, Adrian M., Hardy, Ann, Hight, Craig, Michelle, Carolyn   +3 more
core   +1 more source

Service evaluation to establish the sensitivity, specificity and additional value of broad-range 16S rDNA PCR for the diagnosis of infective endocarditis from resected endocardial material in patients from eight UK and Ireland hospitals [PDF]

, 2014
Infective endocarditis (IE) can be diagnosed in the clinical microbiology laboratory by culturing explanted heart valve material. We present a service evaluation that examines the sensitivity and specificity of a broad-range 16S rDNA polymerase chain ...
Alshafi, K, Gouliouris, T, Harris, KA, Hartley, JC, Jalili, S, Munthali, P, NiRiain, U, Williams, OM, Yam, T   +8 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source