Results 101 to 110 of about 286,454 (307)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Neandertal man the hunter: A history of Neandertal subsistence
, 2010 The history of Neandertals has been examined by a number of researchers who highlight how historical biases have impacted popular and scientific perceptions of Neandertals.
Ready, E.
core
Walter J. Ong, S.J.: A retrospective [PDF]
, 2004 Communication Research Trends usually charts current communication research, introducing its readers to recent developments across the range of inquiry into communication.
Soukup, Paul A.
core +1 more source
In this activity, students focus on the physical and chemical processes associated with the Charleston Bump, a series of rocky scarps, mounds, overhangs, and flat pavements that rise from more than 700 m at the surface of the Blake Plateau to within 400 ...
core +1 more source
Surficial Materials (Diamond Exploration)
, 2010 Minerals associated with diamond source rocks found in glacial sediments indicate presence of a kimberlite. To a certain extent it also gives an evaluation of the potential presence of diamonds. Regional ice advance and retreat pattern knowledge, combined with geophysical analysis, help to find the kimberlites that are the rock formations where ...
openaire +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
[Review of] Diana Der Hovanessian. About Time [PDF]
, 1990 As Armenian American literature matures, the impact of the massacres and dispersion of the Armenians in the Ottoman Empire in 1915 widens in meaning and relevance.
Bedrosian, Margaret
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source