Results 71 to 80 of about 286,454 (307)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

A review on processing polycrystalline magnesium aluminate spinel (MgAl2O4): Sintering techniques, material properties and machinability

open access: yesMaterials & Design, 2020
Transparent polycrystalline magnesium aluminate spinel (PMAS), owing to its high optical transparency with acceptable mechanical properties and chemical stabilities, exhibits great potential for optical applications under extreme environments and ...
Zhuoqi Shi   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

The voice of matter: conjectures about language

open access: yesEstudios de Teoría Literaria, 2022
Between essay, autobiography and fiction, the work Ó (2008), by Brazilian plastic artist and writer Nuno Ramos, tracks several hypotheses, explorations and discourses about the living and its material configurations, cardinal concern of a relevant zone ...
Cecilia Sánchez Idiart
doaj  

Discovery of a two-dimensional topological insulator in SiTe

open access: yes, 2016
Two-dimensional (2D) topological insulators (TIs), a new state of quantum matter, are promising for achieving the low-power-consuming electronic devices owning to the remarkable robustness of their conducting edge states against backscattering. Currently,
Dai, Ying   +3 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Maintenance et attention à la fragilité

open access: yesSociologies, 2020
This article examines the attention to fragility at play in two urban maintenance settings: graffiti removal and water networks management. It shows that maintenance activities consist of situated sensory explorations by which agents become attentive to ...
Jérôme Denis, David Pontille
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Adventurous Upcrafting Ventures

open access: yesCubic Journal, 2018
Since 2015, the Research Institute of Organic Treasures (R.I.O.T.) has combined fermentation practices and social experimentation in Hong Kong to give biological byproducts from human and urban metabolisms a regenerative purpose.
Markus Wernli
doaj   +1 more source

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