Results 71 to 80 of about 286,454 (307)
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Transparent polycrystalline magnesium aluminate spinel (PMAS), owing to its high optical transparency with acceptable mechanical properties and chemical stabilities, exhibits great potential for optical applications under extreme environments and ...
Zhuoqi Shi +4 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
The voice of matter: conjectures about language
Between essay, autobiography and fiction, the work Ó (2008), by Brazilian plastic artist and writer Nuno Ramos, tracks several hypotheses, explorations and discourses about the living and its material configurations, cardinal concern of a relevant zone ...
Cecilia Sánchez Idiart
doaj
Discovery of a two-dimensional topological insulator in SiTe
Two-dimensional (2D) topological insulators (TIs), a new state of quantum matter, are promising for achieving the low-power-consuming electronic devices owning to the remarkable robustness of their conducting edge states against backscattering. Currently,
Dai, Ying +3 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Maintenance et attention à la fragilité
This article examines the attention to fragility at play in two urban maintenance settings: graffiti removal and water networks management. It shows that maintenance activities consist of situated sensory explorations by which agents become attentive to ...
Jérôme Denis, David Pontille
doaj
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Structural biology of ferritin nanocages
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Adventurous Upcrafting Ventures
Since 2015, the Research Institute of Organic Treasures (R.I.O.T.) has combined fermentation practices and social experimentation in Hong Kong to give biological byproducts from human and urban metabolisms a regenerative purpose.
Markus Wernli
doaj +1 more source

