Results 71 to 80 of about 287,684 (305)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Taking stock of the Trinitarian renaissance: What have we learnt?
HTS Teologiese Studies/Theological Studies, 2019 The re-appreciation of the Trinitarian confession in the twentieth century is widely considered a major theological development. Recently, several critical voices emerged, questioning the direction of these explorations.
Rian Venter
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
[Review of] Dirk Hoerder, ed. The Immigrant Labor Press in North America, 1840s-70s (Three volumes) [PDF]
, 1988 Dirk Hoerder has undertaken a truly mammoth task -- the identification, analysis, and the location of surviving collections of the immigrant labor press published in the United States and Canada from the mid-nineteenth century to the present.
Wintz, Cary D.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Language Policy and Language Repression: The Case of Spanish Basques and Mexican Americans [PDF]
, 1993 This paper presents the argument that there are many similarities between the linguistic and cultural repression experienced by Basques in Spain and Mexican Americans in the United States.
Faltis, Deborah
core +1 more source
Kilowatt-scale alkali-cation-free CO2 electrolysis via accelerating mass transfer
Nature CommunicationsElectrocatalytic CO₂ reduction (ECO₂R) presents a sustainable pathway for industrial decarbonization by converting CO₂ into carbon-neutral fuels and chemicals.
Xiaojie She +15 more
doaj +1 more source
Materials & Design, 2020 Transparent polycrystalline magnesium aluminate spinel (PMAS), owing to its high optical transparency with acceptable mechanical properties and chemical stabilities, exhibits great potential for optical applications under extreme environments and ...
Zhuoqi Shi +4 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source