Results 101 to 110 of about 9,803,493 (256)
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Integrated Synthetic Platforms for Chemical Probes: A Journey through the Routes of Flow Processing
, 2017 The talk will focus on our recent efforts directed towards the design and implementation of integrated flow platforms for the production of chemical probes and compound library in drug discovery ...
Gioiello, A.
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
METHOD FOR CONSTRUCTING SIMILARITY CRITERIA FOR STOCHASTIC STATIONARY MATERIAL FLOWS
Сучасні інформаційні системиThe object of the study is a stationary stochastic input flow of material arriving at the input of a transport conveyor system. The goal of the study is to develop methods for comparing such flows based on dimensionless similarity criteria that allow ...
Oleh Pihnastyi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
, 2010 Louis Vuitton’s workshops and their supply chains are continuously changing in order to meet growth in sales and ever-faster product-life cycles. Organizations evolve and new systems are implemented.
Belime, Léo
core
STATIONARY STOCHASTIC INPUT FLOW MODELING OF BRANCHED CONVEYOR SYSTEMS
Сучасні інформаційні системиThe object of research is stochastic stationary input material flow of a conveyor-type transport system. Subject of research is a method for generating realizations of a stationary stochastic input flow of material on the basis of experimental data. The
Oleh Pihnastyi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Analysis of Flow Meters Calibration [PDF]
, 2015 Calibration data of flow meters are often reported using the so called calibration coefficient, i.e. the ratio between the reference flow rate (or equivalent quantity, e.g.
SPAZZINI, PIER GIORGIO +3 more
core