Results 71 to 80 of about 10,167,402 (255)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Material Flow Accounting of Mexico (1970-2003). Sources and Methods [PDF]
This technical background paper describes the methods applied and data sources used in the compilation of the 1980-2003 data set for material flow accounts of the Mexican economy and presents the data set.
Ana Citlalic González Martínez
core
Early-Stage Circularity Assessment in the Manufacturing Industry: The Circularity Score
ProceedingsThe concept of the Circular Economy (CE) has been largely explored by academia, businesses, and governments, driven by growing environmental and economic concerns [...]
Ottavia Aleo +3 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Energy Strategy ReviewsThe expansion of renewable generation, demand response and transmission capacities between electricity markets in different countries and regions change electricity markets by increasing heterogeneity in the cost structure of generation and demand.
Henrik Mantke +4 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Consequential life cycle assessment of demolition waste management in Germany
Frontiers in SustainabilityContextBulk mineral waste materials such as construction and demolition waste are Germany’s largest waste stream. Despite the availability of high-quality recycling pathways such as road base layers, waste concrete is predominantly recycled into lower ...
Christian Dierks +4 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Faster-than-real-time simulation of multi-group pedestrian flow [PDF]
Simulations of pedestrian flow are widely used for design guidelines during the planning of buildings and large events. In this article we discuss how faster-than-real-time simulations of pedestrian flow can contribute to dynamic control strategies of ...
Schwarz, Robin +10 more
core +1 more source