Results 41 to 50 of about 373,182 (301)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Analysis of eigenvalues for problem on the transverse shear crack in material with power defining law

open access: yesVestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2007
We research the non-linear eigenvalues problem which appears from the problem of determining the stress-strain state near the transverse shear crack tip in material with power relationship between strains and stresses.
L. V. Stepanova, M. E. Fedina
doaj   +1 more source

Non-linear Hall effects: Mechanisms and materials

open access: yesMaterials Today Electronics
This review presents recent breakthroughs in the realm of nonlinear Hall effects, emphasizing central theoretical foundations and recent experimental progress. We elucidate the quantum origin of the second-order Hall response, focusing on the Berry curvature dipole, which may arise in inversion symmetry broken systems.
Arka Bandyopadhyay   +2 more
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Charged Pion Energy Reconstruction in the ATLAS Barrel Calorimeter [PDF]

open access: yes, 1999
The intrinsic performance of the ATLAS barrel and extended barrel calorimeters for the measurement of charged pions is presented. Pion energy scans (E = 20, 50, 200, 400 and 1000 GeV) at two pseudo-rapidity points ($\eta$ = 0.3 and 1.3) and ...
Bosman, M., Kulchitsky, Y., Nessi, M.
core   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Non-linear buckling analysis of functionally graded shallow spherical shells

open access: yesVietnam Journal of Mechanics, 2009
In the present paper the non-linear buckling analysis of functionally graded spherical shells subjected to external pressure is investigated. The material properties are graded in the thickness direction according to the power-law distribution in terms ...
Dao Huy Bich
doaj   +1 more source

High frequency electro-optic measurement of strained silicon racetrack resonators

open access: yes, 2015
The observation of the electro-optic effect in strained silicon waveguides has been considered as a direct manifestation of an induced $\chi^{(2)}$ non-linearity in the material.
Bernard, M.   +7 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Response Surfaces in the Numerical Homogenization of Non-Linear Porous Materials

open access: yesEngineering Transactions, 2019
The paper deals with the numerical homogenization of structures made of non-linear porous material. Material non-linearity causes a significant increase in computational costs for numerical homogenization procedure. An application of the response surface
Witold BELUCH, Marcin HATŁAS
doaj   +1 more source

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