Results 61 to 70 of about 373,182 (301)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Non-linear anisotropic hyperelasticity for granular materials [PDF]

open access: yesComputers and Geotechnics, 2019
Abstract We describe a non-linear anisotropic hyperelastic model appropriate for geomaterials, deriving the full stress-strain response from strain energy or complementary energy functions. Specific forms of the functions are chosen so that the stiffness and compliance matrices have the appropriate minor symmetries.
Houlsby, G. T., Amorosi, A., Rollo, F.
openaire   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Non-linear vibration of functionally graded shallow spherical shells

open access: yesVietnam Journal of Mechanics, 2010
The present paper deals with the non-linear vibration of functionally graded shallow spherical shells. The properties of shell material are graded in the thickness direction according to the power law distribution in terms of volume fractions of the ...
Dao Huy Bich, Le Kha Hoa
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Mode switching phenomenon in geometrically nonlinear free vibration analysis of in-plane inhomogeneous plates on elastic foundation

open access: yesCurved and Layered Structures, 2018
Effect of geometric nonlinearity onfree vibration behaviour of a non-uniform in-plane inhomogeneousplate on elastic foundation is carried out with an emphasis on mode switching phenomenon.
Lohar Hareram   +2 more
doaj   +1 more source

Non-linear elastic effects in phase field crystal and amplitude equations: Comparison to ab initio simulations of bcc metals and graphene [PDF]

open access: yes, 2016
We investigate non-linear elastic deformations in the phase field crystal model and derived amplitude equations formulations. Two sources of non-linearity are found, one of them based on geometric non-linearity expressed through a finite strain tensor ...
Friák, M.   +6 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Non-dispersive wavepackets generated in layered structures by a scanning laser source

open access: yesAIP Advances, 2020
In this article, we describe the use of a continuous-wave laser scanning method to generate non-dispersive surface acoustic wavepackets, which propagate along the sample surface without any waveform change.
Zheng Li   +2 more
doaj   +1 more source

Structural Integrity of Functionally Graded Composite Structure using Mindlin-Type Finite Elements. [PDF]

open access: yes, 2008
In this paper, two new Mindlin-type plate bending elements have been derived for the modelling of functionally graded plate subjected to various loading conditions such as tensile loading, in-plane bending and out-of-plane bending.
El-Zafrany, A.   +2 more
core  

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