Results 61 to 70 of about 82,406 (263)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Lattice Boltzmann Solution of Concave Longitudinal Fins under Step-changing base Boundary Conditions Associated with Accumulated Nonlinearity [PDF]

Journal of Applied and Computational Mechanics
This article reports the transient numerical solution of concave profile longitudinal fins under two cases of step-changing base boundary conditions involving heat flux and temperature, respectively.
Abhishek Sahu, Shubhankar Bhowmick
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Large displacement static analysis of a cantilever Timoshenko beam composed of functionally graded material

Science and Engineering of Composite Materials, 2011
In this study, non-linear static analysis of a cantilever Timoshenko beam composed of functionally graded material (FGM) under a non-follower transversal uniformly distributed load is studied with large displacements and large rotations.
Kocatürk Turgut, Şimşek Mesut, Akbaş Şeref Doğuşcan   +2 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Non-linear thermal post-buckling analysis of FGM Timoshenko beam under non-uniform temperature rise across thickness

Engineering Science and Technology, an International Journal, 2016
The present work deals with geometrically non-linear post-buckling load–deflection behavior of functionally graded material (FGM) Timoshenko beam under in-plane thermal loading.
Amlan Paul, Debabrata Das
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Non-linear dynamic response and vibration of an imperfect three-phase laminated nanocomposite cylindrical panel resting on elastic foundations in thermal environments

Science and Engineering of Composite Materials, 2017
This paper presents an analytical approach to investigate the non-linear dynamic response and vibration of an imperfect three-phase laminated nanocomposite cylindrical panel resting on elastic foundations in thermal environments.
Thu Pham Van, Duc Nguyen Dinh
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Version 2.0 – “DYNAblast – A software to obtain the behavior of composite laminated plates subjected to blast loads”

SoftwareX
New structural technologies are constantly being developed, especially in the case of high-impact loads, which cause significant demands on the structure's resistance to collapse.
Ana Waldila de Queiroz Ramiro Reis, Mayara Machado Martins, Rodrigo Bird Burgos   +2 more
doaj   +1 more source