Results 61 to 70 of about 1,398,459 (306)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

BIM-Based Automatic Extraction of Daily Concrete and Formwork Requirements for Site Work Planning

Buildings
Material planning is important in construction, for it affects procurement, cost, and schedule. Proper planning of material supply and logistics helps streamline the performance of all tasks through the avoidance of excessive or insufficient material ...
Van-Hoan Pham, Po-Han Chen, Quan Nguyen, Diep-Thuy Duong   +3 more
doaj   +1 more source

Generative Design In Factory Layout Planning: An Application Of Evolutionary Computing Within The Creation Of Production Logistic Concepts

Proceedings of the Conference on Production Systems and Logistics, 2020
This paper describes the creation and application of a generative design approach in the production logistics layout concept creation as part of factory planning projects.
Dannapfel, Matthias, Vierschilling, Sebastian Patrick, Losse, Stephan, Matzke, Oliver   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Rancang Bangun Sistem Informasi Perencanaan dan Pengawasan Proses Produksi pada CV. Setia Kawan [PDF]

, 2016
CV Setia Kawan is a company that manufactures hydraulic. The production process is based on customer orders received by the Marketing Section, and then forwarded to the Department of Planning.
Arnandy, D. A. (Didiet), Rachman, R. (Rizky), Setyawan, H. B. (Henry)   +2 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Comprehensive Multi-Criteria Decision Making Model for Sustainable Material Selection Considering Life Cycle Assessment Method

IEEE Access, 2018
How to evaluate negative effects of automotive parts on environment in life cycle and select optimal sustainable material are intricate issues. A multi-criteria decision making model combining Techniques for Order Preference by Similarity to an Ideal ...
Fangwu Ma, Ying Zhao, Yongfeng Pu, Jinhang Li   +3 more
doaj   +1 more source

Basic principles of strategic marketing planning business [PDF]

, 2012
В даній статті розглядається термінологія стратегічного маркетингового планування та проводиться оцінка основних принципів побудови стратегічного плану маркетингу на торгово-промислових підприємствах.This article focuses on the terminology of strategic ...
Стефанишин, В. Я.
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source