Results 101 to 110 of about 5,332,166 (340)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

The Dual Origin of the Terrestrial Atmosphere

open access: yes, 2003
The origin of the terrestrial atmosphere is one of the most puzzling enigmas in the planetary sciences. It is suggested here that two sources contributed to its formation, fractionated nebular gases and accreted cometary volatiles.
Abe   +91 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Protocol for preparation of highly durable superhydrophobic bulks with hierarchical porous structures

open access: yesSTAR Protocols
Summary: Superhydrophobic surfaces face challenges in comprehensive durability when used in extreme outdoor environments. Here, we present a protocol for preparing nanocomposite bulks with hierarchical structures using the template technique. We describe
Yunyun Meng   +7 more
doaj   +1 more source

The Sun's Journey Through the Local Interstellar Medium: The PaleoLISM and Paleoheliosphere

open access: yes, 2006
Over the recent past, the galactic environment of the Sun has differed substantially from today. Sometime within the past ~130,000 years, and possibly as recent as ~56,000 years ago, the Sun entered the tenuous tepid partially ionized interstellar ...
Frisch, P. C., Slavin, J. D.
core   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Protocol for modeling and simulating lithiation-induced stress in largely deformed spherical nanoparticles using COMSOL

open access: yesSTAR Protocols
Summary: Here, we present a finite element method-based scheme for solving coupled partial differential equations (PDEs) for the analysis of lithiation-induced stress in largely deformed spherical nanoparticles via the PDE module in COMSOL.
Yong Li   +6 more
doaj   +1 more source

The materials data ecosystem: Materials data science and its role in data-driven materials discovery [PDF]

open access: green, 2018
Hai-Qing Yin   +6 more
openalex   +1 more source

Report on active and planned spacecraft and experiments [PDF]

open access: yes
Information is presented, concerning active and planned spacecraft and experiments known to the National Space Science Data Center. The information included a wide range of disciplines: astronomy, earth sciences, meteorology, planetary sciences, aeronomy,
Horowitz, R.   +2 more
core   +1 more source

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