Results 101 to 110 of about 17,594,294 (300)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Health Sciences Space Planning, 1967-1979 (1)

, 1967
Material is part of University Archives collection #00029.University of Minnesota. Health Sciences Planning Office. (1967). Health Sciences Space Planning, 1967-1979 (1).
University of Minnesota. Health Sciences Planning Office
core  

Protocol for preparation of highly durable superhydrophobic bulks with hierarchical porous structures

STAR Protocols
Summary: Superhydrophobic surfaces face challenges in comprehensive durability when used in extreme outdoor environments. Here, we present a protocol for preparing nanocomposite bulks with hierarchical structures using the template technique. We describe
Yunyun Meng, Binrui Wu, Chaoyi Peng, Suli Xing, Changping Yin, Nan Wu, Manish K. Tiwari, Xian Yi   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Health Sciences Planning Office, 1971-1973

, 1971
Material is part of University Archives collection #00029.University of Minnesota. Health Sciences Planning Office. (1971). Health Sciences Planning Office, 1971-1973.
University of Minnesota. Health Sciences Planning Office
core  

Protocol for modeling and simulating lithiation-induced stress in largely deformed spherical nanoparticles using COMSOL

STAR Protocols
Summary: Here, we present a finite element method-based scheme for solving coupled partial differential equations (PDEs) for the analysis of lithiation-induced stress in largely deformed spherical nanoparticles via the PDE module in COMSOL.
Yong Li, Yunpeng Guo, Yunhao Wu, Yin Rao, Kai Zhang, Dashun Liu, Fuqian Yang   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Health Sciences Planning Committee, 1974-1975 (2)

, 1974
Material is part of University Archives collection #00029.University of Minnesota. Health Sciences Planning Office. (1974). Health Sciences Planning Committee, 1974-1975 (2). Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/
University of Minnesota. Health Sciences Planning Office
core  

Protocol for the preparation and application of CeO2-CuO catalysts in the decarboxylative oxidation reaction of benzoic acids to phenols

STAR Protocols
Summary: Phenolic chemicals are important building blocks in chemical and material industries. In this protocol, we describe the preparation of CeO2-CuO catalysts and the application in the decarboxylative oxidation reaction of benzoic acids to phenols ...
Xinze Du, Yumei Liu, Xiaojun Shen
doaj   +1 more source