Results 41 to 50 of about 726,237 (265)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Hospital wastes management in Mazandaran Province with emphasis on genotoxic waste management

سلامت و محیط, 2019
Background and Objective: Hospital wastes with the content of infectious, pathologic, sharp, pharmaceupitical and genotoxic materials are classified as hazardous wastes.
J Gorgani, R Nabizadeh, M Gholami, H Pasalari, M Yegane Badi, M Farzadkia, HA Asgharnia, MA Zazouli   +7 more
doaj  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Material management and modern methods in hospital

Health Care Academician Journal, 2015
In this study, the health sector to sustain the activities of the most important organizations in hospital supplies and materials aimed to emphasize the importance of management. Starting from the planning of material requirements, the need for a process of procured materials management including elimination of expressing carried out effectively and in
Yasin Uzuntarla, Selahattin Tuncer, Fatih Orhan, Semsettin Varol   +3 more
openaire   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Presenting a Semi-quantitative Model Based on the Resiliency Engineering Management Commitment Index in Assessing the Level of Preparedness Against Emergency Situations of Hospitals in a Fuzzy Environment (Case Study: Selected Faraja Hospitals in 2021) [PDF]

Muhandisī-i bihdāsht-i ḥirfah/ī, 2023
Background and Objective: The main index in resilience engineering is the management commitment index. This study implemented a semi-quantitative risk assessment method based on the fuzzy hierarchical analysis method for the management commitment index ...
Rasoul Jannaty
doaj  

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Medicine demand forecasting: an assessment of a private hospital in Pernambuco

Socioeconomic Analytics
The efficient management of materials in the healthcare sector is crucial to avoid interruptions in the treatment of hospitalized patients, especially when demand is unpredictable and based on criteria of criticality, urgency and clinical status.
Eduardo Fernando da Silva Souza, Antonio Reinaldo Silva Neto   +1 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Risk Assessment of Sari Fatemeh Zahra Hospital Using Failure Mode Effect Analysis, Individualized Rapid Assessment Tool, and Preliminary Hazard Analysis

Journal of Mazandaran University of Medical Sciences, 2018
Background and purpose: Identification of risk in hospital waste management have a major role in reducing the cost of surplus and preventing the spread of diseases.
Tayebeh Mansouri, Mahmoud Alimohammadi, Ramin Nabizadeh Nodehi, Kamyar Yaghmaeian, Ali Azari   +4 more
doaj