Results 91 to 100 of about 1,402,582 (408)

Multi-Nozzle Biopolymer Deposition for Freeform Fabrication of Tissue Constructs [PDF]

open access: yes, 2004
Advanced freeform fabrication techniques have been recently used for the construction of tissue scaffolds because of the process repeatability and capability of high accuracy in fabrication resolution at the macro and micro scales.
Darling, A.   +3 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Synthesis of MnO2–CuO–Fe2O3/CNTs catalysts: low-temperature SCR activity and formation mechanism

open access: yesBeilstein Journal of Nanotechnology, 2019
MnO2–CuO–Fe2O3/CNTs catalysts, as a low-dimensional material, were fabricated by a mild redox strategy and used in denitration reactions. A formation mechanism of the catalysts was proposed. NO conversions of 4% MnO2–CuO–Fe2O3/CNTs catalyst of 43.1–87.9%
Yanbing Zhang   +6 more
doaj   +1 more source

Sustainability in the civil engineering and construction industry: A review

open access: yesJournal of Sustainable Construction Materials and Technologies, 2022
Michael Tiza
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Effect of a novel negative temperature early-strength agent in improving concrete performance under varying curing temperatures

open access: yesCase Studies in Construction Materials
This study investigates the effect of a novel negative temperature early-strength agent (NEA) in enhancing concrete performance under varying curing temperatures, with a discussion on the underlying mechanism through analysis of hydration products and ...
Yasong Zhao   +6 more
doaj   +1 more source

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