Results 101 to 110 of about 416,348 (303)
Case Studies in Construction MaterialsWith the rapid development of the aviation industry, airport pavement is subjected to ever-increasing loads, posing urgent and higher demands on the mechanical performance and durability of pavement materials.
Yingshuo Li +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Structural integrity of engineering components made of functionally graded materials [PDF]
, 2008 Functionally graded materials (FGM) are composite materials with microstructure gradation optimized for the functioning of engineering components. For the case of fibrous composites, the fibre density is varied spatially, leading to variable material ...
Oyekoya, Oyedele O.
core +2 more sources
Case Studies in Construction MaterialsMagnesium oxysulfate (MOS) cement, with its low carbon footprint, faces challenges in water resistance and volume stability. This study examines how fly ash (FA) and ground granulated blast-furnace slag (GGBS) improve MOS cement properties. Findings show
Yasong Zhao +5 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Improving Construction Processes by Integrating Lean, Green, and Six-Sigma [PDF]
, 2013 The overall goal of this research was to develop and implement methods to improve the performance and the efficiency of construction processes prior to and during the construction phase in Design-Bid-Build (DBB) projects.
Banawi, Abdulaziz
core
EngineeringThe conventional method for analyzing the durability of concrete structures is complex and time-consuming. The values of durability parameters are closely linked with the specific mix proportions of concrete and its service environment.
Taotao Feng +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2007 Modern design, construction innovation and maintenance issues have been extensively utilised for composite steel-concrete building structures in Australia.
Uy, Brian, Mendis, Priyan, Ngo, Tuan
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source