Results 101 to 110 of about 373,580 (313)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Designing spray-based 3D printable cementitious materials with fly ash cenosphere and air entraining agent

, 2019
3D printing is a novel construction method, which utilizes sequential deposition of printable material to build structures. It contributes to the automation in civil engineering and offers advantages of design, greenness and efficiency.
Leong, Kah Fai, Qian, Ye, Tan, Ming Jen, Qian, Shunzhi, Lu, Bing, Weng, Yiwei, Li, Mingyang   +6 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Role of Material Structure in Compacted Earthen Building Materials: Implications for Design and Construction [PDF]

, 2011
Rammed earth is an earthen construction material and an ancient construction technique. It is formed by compacting layers of moist sandy loam subsoil into formwork which is then removed, exposing the material and creating a freestanding, monolithic ...
BECKETT, CHRISTOPHER,THOMAS,STONE, Beckett, Christopher Thomas Stone   +1 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Evaluation of erosion control blanket properties and test criteria for specification and design : final report. [PDF]

TR201509A research project to investigate the product approval, design process, and ongoing product evaluation of erosion control blankets(ECBs) for the Missouri Department of Transportation (MoDOT) was conducted.
Cox, Amanda L., Luna, Ronaldo, Sommer, Daniel T., Saint Louis University. Department of Civil Engineering   +3 more
core  

Evaluation of freeze-thaw damage of partially saturated concrete with shrinkage-induced initial damage: Using in-situ CT technique

Developments in the Built Environment
The western plateau of China is marked by low relative humidity (RH) and experiences over 80 freeze-thaw cycles (FTCs) annually. This low RH contributes to shrinkage-induced initial damage in concrete structures before they enter service.
Yanchun Miao, Yanjing Zhang, Xiaobin Dong, Taotao Feng, Zhiqiang Yang, Junlin Lin, Yali Li, Jinyang Jiang, Zeyu Lu   +8 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Ultra-high performance concrete with high strength, workability, loading durability and low curing maintenance for applications in airport pavement

Case Studies in Construction Materials
With the rapid development of the aviation industry, airport pavement is subjected to ever-increasing loads, posing urgent and higher demands on the mechanical performance and durability of pavement materials.
Yingshuo Li, Minghou Li, Lanxin Wang, Liguo Wang, Zhiyong Liu, Jinyang Jiang, Jiawen Zhang   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source