Results 121 to 130 of about 373,580 (313)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A knowledge-based decision support system for roofing materials selection and cost estimating: a conceptual framework and data modelling

, 2009
A plethora of materials is available to the modern day house designer but selecting the appropriate material is a complex task. It requires synthesising a multitude of performance criteria such as initial cost, maintenance cost, thermal performance and ...
Rahman, Sazzadur, Rahman, Sazzadur M., Perera, Srinath (R18622), Perera, Srinath, Bi, Yaxin, Odeyinka, Henry   +5 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Predictive Methods for the Fire Resistance of Single Skin and Sandwich Composite Materials

, 2008
Polymer composite materials are becoming increasingly popular in many engineeringstructures in the civil, aerospace, marine and automotive industries. The increasedstrength and stiffness to weight ratios which are possible with certain types ofcomposites
Cutter, Philip Anthony
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Nonconventional near-infrared room-temperature phosphorescent materials based on spiropolymer alloy

Nature Communications
Near-infrared room-temperature phosphorescent (NIR-RTP) materials feature the advantages of large Stokes shift, long emission lifetime, and high penetration ability, and have been broadly applied in bio-medical imaging, fiber optic telecommunication, and
Yue Ren, Yongfeng Zhang, Han Su, Yeyun Zhao, Wenya Yan, Wenbo Dai, Luojie Zhu, Tao Wang, Jianbing Shi, Junge Zhi, Bin Tong, Peng Sun, Zhengxu Cai, Yuping Dong   +13 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Auburn Science and Engineering Center Construction Site (S2_B6_F7_94)

, 2020
One black and white photographic print of the construction site of the Auburn Science and Engineering Center at The University of Akron. Several bulldozers, trucks, and other construction equipment can be seen clearing the ground to form the foundation ...
University of Akron
core  

Specialist Task Organisations procurement approach for re-engineering construction project processes [PDF]

, 2007
This dissertation provides a framework for improving owners' contracting strategies through a specialist task organisations (STOs) procurement approach for re-engineering construction project processes.
Oyegoke, Adekunle Sabitu
core