Results 121 to 130 of about 416,348 (303)

Canaries nest-inspired assembly of organic-inorganic networks for shotcrete: A rapid setting and hardening strategy via biomimetic design

open access: yesCleaner Materials
Shotcrete is a critical lining material for tunnel constructions. However, previous studies have struggled to simultaneously achieve excellent workability, rapid-setting, high early-strength and superior toughness.
Zhenqi Yu   +8 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Evaluation of erosion control blanket properties and test criteria for specification and design : final report. [PDF]

open access: yes
TR201509A research project to investigate the product approval, design process, and ongoing product evaluation of erosion control blankets(ECBs) for the Missouri Department of Transportation (MoDOT) was conducted.
Cox, Amanda L.   +3 more
core  

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Optimizing cement particle size for strength enhancement and CO₂ reduction in lightweight mortars

open access: yesScientific Reports
This study examines how cement particle size (modified through sieving) affects the fresh and hardened properties of lightweight mortars, with emphasis on early-age microstructural development and environmental performance.
Martyna Nieświec   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Specialist task organisations procurement approach for re-engineering construction project processes [PDF]

open access: yes, 2007
This dissertation provides a framework for improving owners' contracting strategies through a specialist task organisations (STOs) procurement approach for re-engineering construction project processes.
Oyegoke, Adekunle Sabitu
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Auburn Science and Engineering Center Construction (S2_B6_F7_113)

open access: yes, 2020
One black and white photographic print of the concrete shell of the Auburn Science and Engineering Center at The University of Akron during construction.
University of Akron
core  

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