Results 91 to 100 of about 416,348 (303)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Syntheses, characterization, crystal structures and antibacterial activity of pyridine containing hydrazones

Acta Chimica Slovenica
Three new hydrazone compounds derived from 3-pyridinecarboxaldehyde with hydrazides, and two new hydrazone compounds derived from nicotinohydrazide with aldehydes were prepared and characterized by elemental analyses, IR and 1H NMR spectroscopy, and ...
De-Jun Meng, Yan-Chun Hou, Ning Wang, Ming-Jie Ding, Yin-Feng Li   +4 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Indigenous construction materials for theater facilities

, 2020
ERDC TR-13-13 Army Study Program Indigenous Construction Materials for Theater Facilities Engineer Research and Development Center Ghassan Al-Chaar, Lucy A. Whalley, Jonathan T. Beckstrom, H. Garth Anderson, Rosa T. Affleck, Meredith Carr, and Jennifer S.
United States. Army. Corps of Engineers; Engineer Research and Development Center (U.S.); Construction Engineering Research Laboratory (U.S.); Cold Regions Research and Engineering Laboratory (U.S.)
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Construction materials inventory of Neosho County, Kansas

, 1978
Kansas Department of Transportation, Engineering Services Department, Planning and Development Department Prepared in Cooperation with the U.S. Department of Transportation, Federal Highway Administration.

core  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Computer simulation model: Construction Analysis for Pavement Rehabilitation Strategies.

, 2018
Most state highways in the United States were built during the 1960s and 1970s with an infrastructure investment of more than $1 trillion. They now exceed their 20 year design lives and are seriously deteriorated.
Lee, EB, Ibbs, CW
core   +1 more source

Evaluation of freeze-thaw damage of partially saturated concrete with shrinkage-induced initial damage: Using in-situ CT technique

Developments in the Built Environment
The western plateau of China is marked by low relative humidity (RH) and experiences over 80 freeze-thaw cycles (FTCs) annually. This low RH contributes to shrinkage-induced initial damage in concrete structures before they enter service.
Yanchun Miao, Yanjing Zhang, Xiaobin Dong, Taotao Feng, Zhiqiang Yang, Junlin Lin, Yali Li, Jinyang Jiang, Zeyu Lu   +8 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source