Results 121 to 130 of about 1,377,770 (407)

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Ultra-high performance concrete with high strength, workability, loading durability and low curing maintenance for applications in airport pavement

open access: yesCase Studies in Construction Materials
With the rapid development of the aviation industry, airport pavement is subjected to ever-increasing loads, posing urgent and higher demands on the mechanical performance and durability of pavement materials.
Yingshuo Li   +6 more
doaj   +1 more source

A proposal for the maximum use of recycled concrete sand in masonry mortar design

open access: yesMateriales de Construccion, 2016
Natural sand mining from rivers and seashores is causing serious environmental problems in many parts of the world, whereas the fine fraction from recycling concrete waste is underutilized as a construction material. The aim of this paper is to determine
E. Fernández-Ledesma   +4 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Performance and microstructural analysis of modified magnesium oxysulfate cement with additions: Roles of FA and GGBS

open access: yesCase Studies in Construction Materials
Magnesium oxysulfate (MOS) cement, with its low carbon footprint, faces challenges in water resistance and volume stability. This study examines how fly ash (FA) and ground granulated blast-furnace slag (GGBS) improve MOS cement properties. Findings show
Yasong Zhao   +5 more
doaj   +1 more source

Potential Utilization of Waste Material for Sustainable Development in construction Industry

open access: yesInternational journal of recent technology and engineering, 2019
Billions of waste is produced in the world but the wastes are not properly recycled. Recycling of materials also different issues and it needs more energy.

semanticscholar   +1 more source

Project of building a restaurant in Kiev to study the foundation [PDF]

open access: yes, 2019
У проекті будівлі ресторану в Києві з дослідженням фундаменту запропоновано тривимірне планування та інженерно-конструкторські рішення. Розрахунок основних несучих конструкцій. Проведено термотехнічний розрахунок огороджувальних конструкцій.
Tekin, Erdal, Текін, Ердал
core  

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