Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Summary report: A preliminary investigation into the use of fuzzy logic for the control of redundant manipulators [PDF]
The Rice University Department of Mechanical Engineering and Materials Sciences' Robotics Group designed and built an eight degree of freedom redundant manipulator. Fuzzy logic was proposed as a control scheme for tasks not directly controlled by a human
Cheatham, John B., Jr., Magee, Kevin N.
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Research on silicoaluminate-based low-carbon cementitious material—A state-of-the-art review
Fundamental ResearchThe green and low-carbon production of cement is the essential pathway for infrastructure sustainability and the implementation of a dual-carbon strategy.
Jinyang Jiang +4 more
doaj +1 more source
Implantation of Digital Technology in Engineering Education as an Example of Study at Bauman Moscow State Technical University Discipline “Technology of Construction Materials” [PDF]
, 2020 A. F. Tret’yakov +2 more
openalex +1 more source
Analisa Value Engineering pada Proyek Gedung Riset dan Museum Energi dan Mineral Institut Teknologi Bandung [PDF]
, 2014 One of analysis method that used to evaluate the construction project planning is value engineering. The purpose of value engineering are cost saving, performance optimization, and the efficiency of the time, but still consider the function, quality, and
PRATIWI, N. A. (NUR)
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Engineering properties of bio-inspired cement mortar containing seashell powder [PDF]
, 2014 Cement mortar is a semi liquid formed by a composite of cement, sand and water. Generally, cement mortar is used as a medium for bricks laying in construction.
Md. Tahir, Mahmood +2 more
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source