Results 121 to 130 of about 3,200,969 (354)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

NaTiOx‐modified high‐nickel layered oxide cathode for stable sodium‐ion batteries

Carbon Energy
The O3‐type layered cathode with high Ni content has attracted much attention because of its high capacity and simple synthesis process. However, surface side reaction and O3–P3 phase transitions would occur during Na+ insertion/extraction, resulting in ...
Yingcong Liu, Xing Zhou, Dongwei He, Xiaowei Liu, Chao Yang, Dawei Xu, Meilong Wang, Ruitao Sun, Bin Zhang, Jingjing Xie, Jin Han, Wen Chen, Ya You   +12 more
doaj   +1 more source

The materials processing research base of the Materials Processing Center [PDF]

The goals and activities of the center are discussed. The center activities encompass all engineering materials including metals, ceramics, polymers, electronic materials, composites, superconductors, and thin films.
Bowen, H. K., Flemings, M. C., Kenney, G. B.   +2 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Front Cover: Revealing the Impact of Different Iron‐Based Precursors on the ‘Catalytic’ Graphitization for Synthesis of Anode Materials for Lithium Ion Batteries (ChemElectroChem 5/2023) [PDF]

, 2023
Lars Frankenstein, Pascal Glomb, J. Ramírez‐Rico, Martin Winter, Tobias Placke, Aurora Gómez-Martín   +5 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

High-Performance Wide-Temperature Zinc-Ion Batteries with K+/C3N4 Co-Intercalated Ammonium Vanadate Cathodes

Nano-Micro Letters
Highlights Molecular dynamics and experimental results confirm that adjusting the interlayer spacing by changing the C3N4 content effectively improves the reaction kinetics. The synergistic effect of K+ and C3N4 co-intercalation lowers the energy barrier,
Daming Chen, Jimin Fu, Yang Ming, Wei Cai, Yidi Wang, Xin Hu, Rujun Yu, Ming Yang, Yixin Hu, Benjamin Tawiah, Shuo Shi, Hanbai Wu, Zijian Li, Bin Fei   +13 more
doaj   +1 more source

Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds

Nature Communications, 2018
Direct remote C–H functionalization of aliphatic alcohols via alkoxy radicals is largely unexplored. Here, the authors report the C(sp3)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy radicals formed with a hypervalent iodine reagent.
Xinxin Wu, Hong Zhang, Nana Tang, Zhen Wu, Dongping Wang, Meishan Ji, Yan Xu, Min Wang, Chen Zhu   +8 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Direct and efficient synthesis of nucleosides through the ortho-(tert-butylethynyl)phenyl thioglycosides (BEPTs) protocol

Nature Communications
Nucleosides are highly biologically relevant compounds, and are widely clinically used as drugs for the treatment of virus/bacteria infections and cancers.
Hui Liu, Ming-Yang Wang, Hua Xie, Yanli Qiu, Tian Mao, Xiaomei Shen, Xu-Xue Liu, Jing-Jing Guo, Ming-Ze Tang, Jin-Xi Liao, Yuan-Hong Tu, De-Yong Liu, Jian-Song Sun   +12 more
doaj   +1 more source