Results 51 to 60 of about 1,770,357 (219)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Bond line shear strength of structural wood adhesives at high temperatures up to wood carbonization – A classification approach

Results in Engineering
The European timber fire design code EN 1995-1-2 presently specifies that adhesives for timber construction products shall provide integrity throughout the intended fire exposure time, yet no test or requirement specifications are given.
Simon Aicher, Maximilian Henning, Aaron Münzer   +2 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Feasibility Study on Laser Powder Bed Fusion of Ferritic Steel in High Vacuum Atmosphere

Journal of Manufacturing and Materials Processing
The boiling point of metals is dependent on the ambient pressure. Therefore, in laser-based fusion welding and additive manufacturing processes, the resulting process regime, ranging from heat conduction welding to the keyhole mode, is also influenced by
Steffen Fritz, Sven Sewalski, Stefan Weihe, Martin Werz   +3 more
doaj   +1 more source

Friction and Wear Behaviour of Graphite Filled Polymer Composites in Hydrogen Environment

Tribology Online, 2015
High performance polymer composites have been intensively investigated for tribological applications in air, but rarely in hydrogen environment. Author’s previous benchmark of composites in liquid hydrogen (LH2) showed that graphite filled polymers have ...
Géraldine Theiler, Thomas Gradt
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Embedding and cross-sectioning as a sample preparation procedure for accurate and representative size and shape measurement of nanopowders

Scientific Reports
Reliable measurement of the size of polydisperse, complex-shaped commercial nanopowders is a difficult but necessary task, e.g., for regulatory requirements and toxicity risk assessment.
Paul Mrkwitschka, Bastian Rühle, Petra Kuchenbecker, Oliver Löhmann, Franziska Lindemann, Vasile-Dan Hodoroaba   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Current Trends in Integration of Nondestructive Testing Methods for Engineered Materials Testing. [PDF]

Sensors (Basel), 2021
Kumpati R, Skarka W, Ontipuli SK.
europepmc   +1 more source