Results 161 to 170 of about 2,492,496 (256)

PBPK Models for Fetal Drug Exposure: A Critical Assessment of Current Approaches and Regulatory Readiness. [PDF]

J Clin Pharmacol
Dallmann A, Butler A, Fischer-Holzhausen S, Kerwash E, Macente J, Nauwelaerts N, Illamola SM, Rowland Yeo K, Knöchel J.   +8 more
europepmc   +1 more source

Molecular Regulation of Post‐Hatching Embryo Development: Implications for Early Pregnancy Losses in Livestock Species

Reproduction in Domestic Animals, Volume 61, Issue S3, October 2026.
ABSTRACT Pregnancy loss (PL) remains a major limitation to reproductive efficiency in livestock, with a substantial proportion originating during early embryo development, particularly between blastocyst hatching and implantation. This developmental window encompasses complex processes of lineage differentiation and morphogenesis. Accumulating evidence
Alexia Siegmund‐Sabater, Nuria Martínez de los Reyes, Inés Flores‐Borobia, Leopoldo González‐Brusi, Beatriz Galiano‐Cogolludo, Pilar Marigorta, Pablo Bermejo‐Álvarez, Priscila Ramos‐Ibeas   +7 more
wiley   +1 more source

Maternal kidney adaptation and function in pregnancy: review and perspectives. [PDF]

Function (Oxf)
Hebert JF, Burfeind K, Hutchens MP.
europepmc   +1 more source

Atypical protein kinase C iota (PKCλ/ι) ensures mammalian development by establishing the maternal-fetal exchange interface.

Atypical protein kinase C iota (PKCλ/ι) ensures mammalian development by establishing the maternal-fetal exchange interface.
学術論文(Ariticle)
openaire   +1 more source

Metformin Inhibits Trophoblast Ferroptosis by Suppressing ATF2 and Activating the PI3K/Akt/Nrf2 Pathway to Improve Gestational Diabetes Mellitus

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Metformin suppresses ATF2 expression, activating the PI3K/Akt pathway and promoting Nrf2 nuclear translocation. This upregulates GPX4, inhibiting ferroptosis in trophoblast cells. Erastin blocks system Xc−, depleting GSH and promoting ferroptosis. LY294002 and ML385 inhibit the pathway, validating the mechanism.
Dandan Xia, Yuhui Zhang, Wenjie Liu, Siyu Li, Chenying Zhang, Guangtong She, Huiyan Wang   +6 more
wiley   +1 more source

The human placenta development and anatomy. [PDF]

Arch Gynecol Obstet
Quaye D, Appiah PO, Obiri D, Ahenkorah J, Adu-Bonsaffoh K.   +4 more
europepmc   +1 more source

An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Integrated quantitative proteomic, phosphoproteomic, and transcriptomic analyses of human trophoblast stem cells identify stage‐specific kinase signaling networks that regulate trophoblast self‐renewal and differentiation into syncytiotrophoblasts and extravillous trophoblasts.
Rajnish Kumar, Purbasa Dasgupta, Soma Ray, Soumen Paul   +3 more
wiley   +1 more source

Clinical Significance of Maternal Anti-D Antibody Titers in Severe RhD Alloimmunization Requiring Intrauterine Transfusion: A Tertiary Referral Center Experience. [PDF]

J Clin Med
Aykut S, Evrüke İC, Demir SC, Yalçın E, Kurt A, Nessar AZ.   +5 more
europepmc   +1 more source

Critical Care-Based Decision-Making and Timing of Pregnancy Termination in Hypertriglyceridemia-Induced Acute Pancreatitis Complicated by Diabetic Ketoacidosis and Intrauterine Fetal Demise: A Case Report. [PDF]

Case Rep Crit Care
Hu Y, Mao Y, Gao H.
europepmc   +1 more source

Abnormal Intrapartum Cardiotocographic Tracing, Fetal Outcome and Placental Pathology. [PDF]

Diagnostics (Basel)
Nardi E, Grassi S, Costantino A, Simeone S, Castiglione F, Oliva A, Arena V.   +6 more
europepmc   +1 more source