Results 91 to 100 of about 9,803,652 (406)

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

open access: yesAdvanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang   +4 more
wiley   +1 more source

Exercise epigenetics and the foetal origins of disease [PDF]

open access: yes, 2014
Exercise epigenetics is a nascent area of research with vast health implications (e.g., from the treatment of obesity-related diseases to beneficially decoupling epigenetic and chronological age).
Dale E, Thomas EW Chalk, William M Brown
core   +1 more source

Maternal age, parity, and pregnancy estrogens

open access: yesCancer Causes and Control, 1990
Total estrogens (TE), estradiol (E2), estriol (E3), and human placental lactogen (hPL) were determined by radioimmunoassay in the blood of 126 pregnant women during their 26th and 31st weeks of pregnancy and the results were studied in relation to maternal age and parity.
PANAGIOTOPOULOU, K   +5 more
openaire   +4 more sources

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

open access: yesAdvanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv   +8 more
wiley   +1 more source

Inhibitory control as a mediator of bidirectional effects between early oppositional behavior and maternal depression. [PDF]

open access: yes, 2014
Maternal depression is an established risk factor for child conduct problems, but relatively few studies have tested whether children's behavioral problems exacerbate mothers' depression or whether other child behavioral characteristics (e.g., self ...
Brennan, Lauretta M   +4 more
core   +1 more source

Current status of laboratory and imaging diagnosis of neonatal necrotizing enterocolitis

open access: yesItalian Journal of Pediatrics, 2018
Necrotizing enterocolitis continues to be a devastating disease process for very low birth weight infants in Neonatal Intensive Care Units. The aetiology and pathogenesis of necrotizing enterocolitis are not definitively understood.
Gabriella D’Angelo   +9 more
doaj   +1 more source

Advanced maternal age: maternal and perinatal outcomes

open access: yesInternational Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2023
Background: Advanced maternal age is significantly associated with adverse obstetrical outcomes like pregnancy-induced hypertension and preterm Delivery. Caesarean delivery is also increased in those mothers. Advanced maternal age pregnancy was also found to be a major risk factor for low birth-weight and perinatal death.
openaire   +1 more source

Overlooked roles of DNA damage and maternal age in generating human germline mutations

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2018
Significance More than three-fourths of human germline mutations are paternal in origin and their total number increases with the father’s age at conception.
Ziyue Gao   +7 more
semanticscholar   +1 more source

CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7‐Positive Vesicle Fusion with Target Membranes

open access: yesAdvanced Science, EarlyView.
CCDC41 is essential for meiotic maturation in mouse oocytes through regulating Rab7‐positive endosomes fusion with lysosomes and Rab11a‐positive vesicle fusion with the plasma membrane. Abstract Coiled‐coil domain‐containing protein 41 (CCDC41), a core component of centriolar distal appendages involved in centriole assembly and ciliary vesicle docking,
Ying Tian   +12 more
wiley   +1 more source

Prevalence of exclusive breastfeeding and its determinants in first 6 months of life: A prospective study [PDF]

open access: yes, 2009
Background: Exclusive breastfeeding for first 6 months of life is recommended under Infant and Young Child Feeding practices in India. The objective of present study was to estimate the prevalence of exclusive breastfeeding during first 6 months of life ...
Amin, Chikitsa D   +2 more
core   +1 more source

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