Results 91 to 100 of about 5,793,459 (255)

A Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence

Advanced Science, EarlyView.
Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Xiaoxia Chang, Jiaxin Yu, Hangkun Yu, Chunxia Gong, Jie Xiong, Philip N. Baker, Yong Fu, Chao Tong   +11 more
wiley   +1 more source

Maternal Age, Abortion and Aneuploidy

Indonesian Journal of Obstetrics and Gynecology, 2016
N ...
Andon Hestiantoro
doaj   +1 more source

Maternal age, parity, and pregnancy estrogens

Cancer Causes and Control, 1990
Total estrogens (TE), estradiol (E2), estriol (E3), and human placental lactogen (hPL) were determined by radioimmunoassay in the blood of 126 pregnant women during their 26th and 31st weeks of pregnancy and the results were studied in relation to maternal age and parity.
PANAGIOTOPOULOU, K, KATSOUYANNI, K, PETRIDOU, E, GARAS, Y, TZONOU, A, TRICHOPOULOS, D   +5 more
openaire   +4 more sources

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Interactive Effects of Parental Age on Adverse Birth Outcomes in Japan: An Investigation of Nationwide Birth Data [PDF]

Journal of Preventive Medicine and Public Health
Objectives We investigated the interactive effects of parents’ ages, as well as the overall effects of paternal age, on adverse birth outcomes using nationwide data from Japan.
Tasuku Okui
doaj   +1 more source

Maternal Age and Developmental Variability

Journal of Experimental Biology, 1962
ABSTRACT Evidence is presented showing that in Drosophila egg-length variability and stemo-pleural chaeta number asymmetry, which are both measures of developmental stability, usually increase with age parabolically, so that both these characters decrease at first to a minimum between the 5th and 12th days of maternal age, then increase ...
openaire   +3 more sources

Meta-Analysis The Effect of Maternal Obesity on the Risk of Premature Birth and Neonatal Death

, 2021
Background: The prevalence of obesity in women of reproductive age worldwide is increasing by an estimated 20-36%. Increased prevalence of obesity also occurs in pregnant women. Obesity increases the risk of poor pregnancy outcome.
Budihastuti, Uki Retno, Wulandari, Fitria, Pamungkasari, Eti Poncorini   +2 more
core  

Targeting Macrophage‐Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation

Advanced Science, EarlyView.
Incomplete microwave ablation induces animmunosuppressive microenvironment in tumor‐draining lymph nodes. An albumin‐based lipoprotein nanosystem enables coordinated delivery of immunomodulators to tumor‐draining lymph nodes and residual tumors, reverses post‐ablation immunosuppression, suppresses residual tumor growth, and promotes durable antitumor ...
Xuexia Shan, Yuting Shen, Xiaodong Hou, Fengshan Jin, Shaoyue Li, Weichen Xu, Weiwei Ren, Xiaowan Bo, Qiuyan Li, Shuo Liu, Weifan Hao, Chengzhong Peng, Huixiong Xu, Liping Sun, Wenwen Yue   +14 more
wiley   +1 more source

MATERNAL AGE AND FOETAL OXYGENATION [PDF]

Obstetrical & Gynecological Survey, 1957
E P, TURNBULL, D, BAIRD
openaire   +2 more sources

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source