Results 121 to 130 of about 10,926,372 (352)

Why are so many Nepali women killing themselves? A review of key issues [PDF]

, 2015
Background: For decades the maternal mortality in Nepal was the lead cause of death among women, with great improvements in the maternal mortality ratio in the twentieth century the second most common cause has become more prominent.
Dhungel, A., Fanning, C., Marahatta, S. B., Simkhada, Padam, van Teijlingen, Edwin, Winter, R. C.   +5 more
core   +1 more source

New observations on maternal age effect on germline de novo mutations

Nature Communications, 2016
Germline mutations are the source of evolution and contribute substantially to many health-related processes. Here we use whole-genome deep sequencing data from 693 parents–offspring trios to examine the de novo point mutations (DNMs) in the offspring ...
Wendy S. W. Wong, B. Solomon, D. Bodian, Prachi Kothiyal, G. Eley, Kathi Huddleston, Robin L. Baker, D. Thach, R. Iyer, J. Vockley, J. Niederhuber   +10 more
semanticscholar   +1 more source

Real‐World Trends in Prenatal Antirheumatic Drug Utilization in Ontario, Canada: A Cross‐Sectional Time‐Series Analysis

Arthritis Care &Research, EarlyView.
Objective This study aimed to describe real‐world trends in preconception and prenatal use of antirheumatic drugs among pregnant individuals with rheumatic diseases in Ontario, Canada. Methods We conducted a time‐series analysis using repeated cross‐sectional data to examine annual patterns of disease‐modifying antirheumatic drug (DMARD) use among ...
Shenthuraan Tharmarajah, Swaleh Hussain, Sara J. T. Guilcher, Lisa M. McCarthy, Dharini Mahendira, Howard Berger, Mina Tadrous   +6 more
wiley   +1 more source

Early risk factors for adolescent antisocial behaviour: an Australian longitudinal study [PDF]

, 2004
Objective: This investigation utilizes data from an Australian longitudinal study to identify early risk factors for adolescent antisocial behaviour.
Achenbach T M, Achenbach T M, Australian Bureau of Statistics, Bracken B A, Cravioto J, Dunn L M, Farrington D P, Huesmann L R, Kazdin A, Lipsey M W, Malmgren K W, Menard S, Moffitt T E, Mukherjee S, National Crime Prevention, Prior M, Rutter M, Sanders M R, Silburn S R, van Kesteren J, Wasserman G A   +20 more
core   +2 more sources

Effects of maternal age on euploidy rates in a large cohort of embryos analyzed with 24-chromosome single-nucleotide polymorphism-based preimplantation genetic screening.

Fertility and Sterility, 2016
OBJECTIVE To determine the effect of maternal age on the average number of euploid embryos retrieved during oocyte harvest as part of an in vitro fertilization (IVF) cycle, including the probability of retrieving at least one euploid embryo in a cohort ...
Z. Demko, Alexander L. Simon, R. McCoy, D. Petrov, M. Rabinowitz   +4 more
semanticscholar   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Birth seasonality studies in a large Prader-Willi syndrome cohort. [PDF]

, 2019
Prader-Willi syndrome (PWS) is generally due to sporadic paternal deletions of the chromosome 15q11-q13 region followed by maternal disomy 15. Advanced maternal age is more commonly seen in those with maternal disomy 15. Environmental factors (e.g., drug
Butler, Merlin G, Driscoll, Daniel J, Dykens, Elisabeth, Gold, June Anne, Kimonis, Virginia, Miller, Jennifer L, Tamura, Roy   +6 more
core   +1 more source

Pregnancy at very advanced maternal age: a UK population‐based cohort study

BJOG: an International Journal of Obstetrics and Gynaecology, 2016
To describe the characteristics, management and outcomes of women giving birth at advanced maternal age (≥48 years).
Kathryn Fitzpatrick, D. Tuffnell, Jenny J. Kurinczuk, M. Knight   +3 more
semanticscholar   +1 more source

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Maternal-fetal attachment among Vietnamese mothers in the first, second, and third trimesters of pregnancy: A pilot study. [PDF]

, 2004
Purpose: The purpose of this study was to investigate maternal-fetal attachment (MFA) among Vietnamese women during pregnancy. Design: This study is a quantitative, descriptive pilot study of maternal fetal attachment among twenty-five Vietnamese women ...
Choo, Barbara
core   +1 more source