The long-term effects of maternal deprivation on the number and size of inhibitory interneurons in the rat amygdala and nucleus accumbens [PDF]
Frontiers in Neuroscience, 2023 IntroductionThere is an increasing evidence supporting the hypothesis that traumatic experiences during early developmental periods might be associated with psychopathology later in life.
Dubravka Aleksic +9 more
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Neurobiological mechanisms involved in maternal deprivation-induced behaviours relevant to psychiatric disorders [PDF]
Frontiers in Molecular Neuroscience, 2023 Parental care is essential for proper development of stress response and emotion-related behaviours. Epidemiological studies show that parental loss in childhood represents a major risk factor for the development of mental disorders throughout the ...
Natália Cristina Zanta +2 more
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Downregulation of GRK6 in arcuate nucleus promotes chronic visceral hypersensitivity via NF-κB upregulation in adult rats with neonatal maternal deprivation [PDF]
Molecular Pain, 2020 Aims The arcuate nucleus is a vital brain region for coursing of pain command. G protein-coupled kinase 6 (GRK6) accommodates signaling through G protein-coupled receptors.
Xin Li +7 more
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The impact of early life maternal deprivation on the perineuronal nets in the prefrontal cortex and hippocampus of young adult rats [PDF]
Frontiers in Cell and Developmental Biology, 2022 Early life stress negatively impacts brain development and affects structure and function of parvalbumin immunopositive (PV+) inhibitory neurons. Main regulators of PV+ interneurons activity and plasticity are perineuronal nets (PNNs), an extracellular ...
Ana Jakovljevic +8 more
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Maternal Deprivation in Rats Decreases the Expression of Interneuron Markers in the Neocortex and Hippocampus [PDF]
Frontiers in Neuroanatomy, 2021 Early life stress has profound effects on the development of the central nervous system. We exposed 9-day-old rat pups to a 24 h maternal deprivation (MD) and sacrificed them as young adults (60-day-old), with the aim to study the effects of early stress
Milan Aksic +10 more
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Maternal Deprivation Increased Vulnerability to Depression in Adult Rats Through DRD2 Promoter Methylation in the Ventral Tegmental Area [PDF]
Frontiers in Psychiatry, 2022 ObjectiveEarly life adversity is a risk factor for depression in adulthood; however, the underlying mechanisms are not well understood. This study aims to investigate the effect of DNA methylation of DRD2 gene on early life stress–induced depression in ...
Zhenli Guo +8 more
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Spatial Learning Is Impaired in Male Pubertal Rats Following Neonatal Daily but Not Randomly Spaced Maternal Deprivation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Severe early life stress has long been associated with neuropsychological disorders in adulthood, including depression, schizophrenia, post-traumatic stress disorder, and memory dysfunction.
Emily T. Stoneham +7 more
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Sensitization of P2X3 receptors in insular cortex contributes to visceral pain of adult rats with neonatal maternal deprivation [PDF]
Molecular Pain, 2018 Aims Insular cortex is a brain region critical for processing of the sensation. Purinergic receptors are involved in the formation of chronic pain. The aim of the present study was to explore the role and mechanism of P2X3 receptors (P2X3Rs) in insular ...
Ping-An Zhang +5 more
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Maternal deprivation and the development of stereotypic behaviour [PDF]
Applied Animal Behaviour Science, 2008 Many farm, laboratory, zoo and companion animals experience some form of maternal deprivation. This is typically via separation from their mothers earlier than would happen in free-living populations, in some cases even while young are still dependent upon milk.
Mason, G.J., Latham, N.
exaly +3 more sources
Effects of Maternal Deprivation and Complex Housing on Rat Social Behavior in Adolescence and Adulthood [PDF]
Frontiers in Behavioral Neuroscience, 2018 Early life context and stressful experiences are known to increase the risk of developing psychiatric disorders later in life, including disorders with deficits in the social domain.
Jiska Kentrop +9 more
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