Results 51 to 60 of about 122,701 (333)

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

open access: yesAdvanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo   +3 more
wiley   +1 more source

Neonatal stress-induced affective changes in adolescent Wistar rats: early signs of schizophrenia-like behavior

open access: yesFrontiers in Behavioral Neuroscience, 2014
Psychiatric disorders are multifactorial diseases with etiology that may involve genetic factors, early life environment and stressful life events. The neurodevelopmental hypothesis of schizophrenia is based on a wealth of data on increased vulnerability
Carlos Eduardo Neves Girardi   +2 more
doaj   +1 more source

‘This growing genetic disaster’: obesogenic mothers, the obesity ‘epidemic’ and the persistence of eugenics [PDF]

open access: yes, 2013
In this era of ever-increasing emphasis on personal responsibility the 'obesity epidemic', officialised in global health warnings, threatens to swamp the West with the consequences of overindulgence.
Cain, Ruth
core   +2 more sources

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

open access: yesAdvanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang   +12 more
wiley   +1 more source

The Relationship Between Parental Psychological Control and College Students’ Non-Suicidal Self-Injury: The Chain Mediation Roles of Relative Deprivation and Depression and the Moderating Role of Peer Relationships

open access: yesBehavioral Sciences
Previous research has demonstrated that parental psychological control increases the likelihood of non-suicidal self-injury (NSSI) among college students. However, the underlying mechanisms of this association remain unclear.
Sachula Cui, Qiang Bao
doaj   +1 more source

Maternal Separation and the Risk of Drug Abuse in Later Life [PDF]

open access: yesAddiction and Health, 2016
Maternal separation (MS) is defined as the termination of the continuity of mother-child relationship after the relationship is established. Although MS and maternal deprivation are different in terms of their definitions, these two terms are usually ...
Fatemeh Delavari   +3 more
doaj  

The impact of the mother on the hypothalamic-pituit aryadrenal, hypothalamic-pituit ary-gonadal and somatotropic axes activity of offspring during postnatal ontogeny

open access: yesActa Biologica, 2015
During the rearing period, most of the physiological processes of offspring are under maternal regulation, which overcomes the influence of external environmental factors.
Natalia Chmielewska, Marta Wańkowska
doaj   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

open access: yesAdvanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang   +11 more
wiley   +1 more source

Multisectoral Convergence of Food, Nutrition and Sanitation Programs for Child Health: Evidence From Country‐Level Programs in India

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT This paper underscores the critical role of multisectoral convergence in enhancing child health, particularly in addressing anemia, a micronutrient deficiency linked to both diet and sanitation. We explore how the integration of nationwide food and nutrition programs with sanitation initiatives impacts anemia in Indian children under three ...
Soumya Gupta, Payal Seth, Prabhu Pingali
wiley   +1 more source

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