Results 71 to 80 of about 2,400,816 (305)

Maternal Exposure to Amoxicillin and the Risk of Oral Clefts [PDF]

Epidemiology, 2012
Prior studies have suggested an increased risk of oral clefts after exposure to amoxicillin in early pregnancy, but findings have been inconsistent.Among participants in the Slone Epidemiology Center Birth Defects Study from 1994 to 2008, we identified 877 infants with cleft lip with/without cleft palate and 471 with cleft palate alone.
Lin, K.J., Mitchell, A.A., Yau, W.-P., Louik, C., Hernández-Díaz, S.   +4 more
openaire   +2 more sources

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Effects of Prenatal Exposure to Ozone, Heatwave and Green Space on Neonatal Congenital Heart Disease: A Case-Control Study in Eastern China

Toxics
Congenital heart disease (CHD) is the most prevalent birth defect. Ozone and heatwave exposure during pregnancy could increase the risk of adverse birth outcomes. Green space might be associated with beneficial birth outcomes.
Weizhe Zhang, Tiezheng Li, Leiyu Shi, Die Li, Mary A. Fox   +4 more
doaj   +1 more source

Nausea During Pregnancy and Timing of Pubertal Development in Sons and Daughters: A Population-Based Cohort Study

Clinical Epidemiology, 2021
Mette Rahbek Bruun,1 Andreas Ernst,1,2 Linn Håkonsen Arendt,1,3 Cecilia Høst Ramlau-Hansen,1 Nis Brix1,4 1Department of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, Denmark; 2Department of Urology, Aarhus University Hospital,
Bruun MR, Ernst A, Arendt LH, Ramlau-Hansen CH, Brix N   +4 more
doaj  

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Maternal high-fat diet and risk of cardiovascular disease in offspring: a review of mechanisms, controversies, and interventions

Experimental Biology and Medicine
A high-fat diet (HFD) is a well-established risk factor for coronary artery disease (CAD). Accumulating evidence indicates that maternal nutritional status before and during pregnancy critically influences long-term cardiovascular outcomes in offspring ...
Heyu Meng, Jianjun Ruan, Qing Wang, Fanbo Meng   +3 more
doaj   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

Single-cell RNA sequencing across diverse cell types to identify PFOA-induced ovarian cellular senescence

Ecotoxicology and Environmental Safety
Perfluorooctanoic acid (PFOA) is a persistent environmental pollutant that has been associated with reproductive dysfunction, yet cellular mechanism underlying its ovarian toxicity remain poorly understood. From the perspective of cellular senescence, we
Ning Li, Jiahao Hu, Yuhan Zhao, Jiaqi Tian, Qiang Li, Lin Zhang   +5 more
doaj   +1 more source

Early exposure to toxic metals has a limited effect on blood pressure or kidney function in later childhood, rural Bangladesh. [PDF]

, 2012
BACKGROUND: Chronic exposure to toxic metals such as arsenic and cadmium has been implicated in the development of kidney and cardiovascular diseases but few studies have directly measured exposure during inutero and early child development.
Fulford, Anthony JC, Persson, Lars-Ake, Vahter, Marie, Arifeen, SE, Kippler, M,, Wagatsuma, Yukiko, Hawkesworth, Sophie, Persson, L-A, Vahter, M,, Hawkesworth, S, Fulford, AJC, Kippler, Maria, Moore, SE, Moore, Sophie E, Fulford, Anthony J. C., Wagatsuma, Y, Moore, Sophie E., Arifeen, Shams E, Arifeen, Shams E., Persson, Lars-Ake,   +19 more
core   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source