Results 161 to 170 of about 261,235 (310)

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

N-acetylcysteine Restores Impaired Dentate Gyrus Neurogenesis in a Neonatal Maternal Separation Rat Model. [PDF]

Exp Neurobiol
Kim HB, Kim YJ, Lim HM, Suh SW, Lee JH, Lee CJ, Woo RS.   +6 more
europepmc   +1 more source

Maternal separation differentially modulates early pathology by sex in 5xFAD Alzheimer's disease-transgenic mice. [PDF]

Brain Behav Immun Health, 2023
Garcia MG, Paulus A, Vázquez-Reyes S, Klementieva O, Gouras GK, Bachiller S, Deierborg T.   +6 more
europepmc   +1 more source

Do Dads matter? Or is it just their money that matters? Unpicking the effects of separation on educational outcomes by and [PDF]

The widely held view that separation has adverse effects on children has been the basis of important policy interventions. While a small number of analyses have been concerned with selection into divorce, no studies have attempted to separate out the ...
Ian Walker, Yu Zhu
core  

ANK1 and EPB41 Variants and The Risk of Steroid‐Induced Osteonecrosis

Arthritis &Rheumatology, Accepted Article.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Dysfunction of the paraventricular thalamus-prelimbic cortex circuit underlies maternal separation-induced deficits in contagious pain. [PDF]

Sci Adv
Zhang Z, Gong Y, Su XY, Deng Y, Du R, Li CL, Wang Y, Song XL, Jiang Q, Li Y, Jian Y, Tong X, Wang GH, Chen J, Xu TL, Liu MG, Jiang F.   +16 more
europepmc   +1 more source

Maternal separation modifies spontaneous synaptic activity in the infralimbic cortex of stress-resilient male rats. [PDF]

PLoS One, 2023
Ayala-Rodríguez JD, García-Colunga J.
europepmc   +1 more source

Modern competency‐based teaching of human sexual development

Anatomical Sciences Education, EarlyView.
Abstract Embryology is an integral part of anatomy and a key subject in basic medical education. The development of the sexual tract, which is closely associated with the formation of the urinary tract and the organs of continence, is particularly complex and relevant for many medical disciplines.
Elisabeth Eppler, Alessandro Bilella, Christian M. Hammer   +2 more
wiley   +1 more source

Maternal Separation and Negative Renal Programming, Evidence of Morphofunctional Alterations in Rodent Models: Systematic Review and Meta-Analysis. [PDF]

Int J Mol Sci
Duque-Colorado J, Rivadeneira J, Vásquez B.   +2 more
europepmc   +1 more source

Maternal separation and its developmental consequences on anxiety and parvalbumin interneurons in the amygdala. [PDF]

J Neural Transm (Vienna), 2023
Abraham M, Schmerder K, Hedtstück M, Bösing K, Mundorf A, Freund N.   +5 more
europepmc   +1 more source