Results 191 to 200 of about 87,037 (303)

Maternal separation modifies spontaneous synaptic activity in the infralimbic cortex of stress-resilient male rats. [PDF]

PLoS One, 2023
Ayala-Rodríguez JD, García-Colunga J.
europepmc   +1 more source

Mothers’ lived experience of maternal separation: a phenomenological exploration

There is little literature on the topic of maternal separation from an existential philosophical perspective. An existential-phenomenological approach provides a thorough and organised analysis of maternal separation by examining the various aspects of ...
Franklin, N.
core  

Impact of Early Postnatal Maternal Separation Stress on Pancreatic Function in Rodents: A Systematic Review and Meta-Analysis. [PDF]

Int J Mol Sci
García-Orozco L, Rivadeneira J, Vásquez B.   +2 more
europepmc   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Exploration of intervention strategies for alleviating maternal separation anxiety from the perspective of obstetrics and neonatology collaboration. [PDF]

Medicine (Baltimore)
Chen X, Yao L, Pi X.
europepmc   +1 more source

An enriched environment ameliorates the reduction of parvalbumin-positive interneurons in the medial prefrontal cortex caused by maternal separation early in life. [PDF]

Front Neurosci, 2023
Irie K, Ohta KI, Ujihara H, Araki C, Honda K, Suzuki S, Warita K, Otabi H, Kumei H, Nakamura S, Koyano K, Miki T, Kusaka T.   +12 more
europepmc   +1 more source

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

British Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert, Carl M. J. Kirkpatrick, Rory Marriott, Siladitya Ray Chaudhuri, David Polidori, Bart Remmerie, Michelle P. McIntosh   +6 more
wiley   +1 more source

Gallic acid alleviates visceral hyperalgesia following maternal separation in mice by inhibiting EphrinB2/EphB2 signaling mediated activation of neurons and glial cells. [PDF]

Front Immunol
Guo SF, Wang Y, Zheng H, Tu HQ, Xi YQ, Li D, Ma ZL, Zhang W, Ruan JP.   +8 more
europepmc   +1 more source

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, EarlyView.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

Effects of maternal separation on punishment-driven risky decision making in adolescence and adulthood. [PDF]

Neurobiol Learn Mem
Minnes GL, Wiener AJ, Pisahl AS, Duecker EA, Baskhairoun BA, Lowe SC, Simon NW.   +6 more
europepmc   +1 more source