Results 31 to 40 of about 2,071,672 (242)

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

The effects of maternal separation on behaviours under social-housing environments in adult male C57BL/6 mice

Scientific Reports, 2021
Adverse experience in early life can affect the formation of neuronal circuits during postnatal development and exert long-lasting influences on neural functions that can lead to the development of a variety of psychiatric disorders including depression,
Nozomi Endo, Manabu Makinodan, Takayo Mannari-Sasagawa, Noriko Horii-Hayashi, Nami Somayama, Takashi Komori, Toshifumi Kishimoto, Mayumi Nishi   +7 more
doaj   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Maladaptive cognitive appraisals in children with high-functioning autism : associations with fear, anxiety and theory of mind [PDF]

, 2014
Despite the well-documented success of cognitive restructuring techniques in the treatment of anxiety disorders, there is still little clarity on which cognitions underpin fear and anxiety in children with high-functioning spectrum disorders (HFASD ...
Sharma, Shilpi, Hunter, Simon C., Woolfson, Lisa   +2 more
core   +4 more sources

Transgenerational improvements following child anxiety treatment: An exploratory examination.

PLoS ONE, 2019
BACKGROUND:The present study conducted secondary analyses of a randomized controlled trial to examine the transgenerational relationship between cognitive-behavioral therapy for child Separation Anxiety Disorder (SepAD) and the mental health of parents ...
Kristen Lavallee, Kathrin Schuck, Judith Blatter-Meunier, Silvia Schneider   +3 more
doaj   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Corticotropin-Releasing Factor Receptor 1 in the Anterior Cingulate Cortex Mediates Maternal Absence-Induced Attenuation of Transport Response in Mouse Pups

Frontiers in Cellular Neuroscience, 2018
A human infant initially shows non-selective sociality, and gradually develops selective attachment toward its caregiver, manifested as “separation anxiety.” It was unclear whether such sophistication of attachment system occurs in non-human mammals.
Sachine Yoshida, Sachine Yoshida, Sachine Yoshida, Ryuko Ohnishi, Ryuko Ohnishi, Yousuke Tsuneoka, Yousuke Tsuneoka, Yuka Yamamoto-Mimura, Reiko Muramatsu, Tadafumi Kato, Hiromasa Funato, Hiromasa Funato, Kumi O. Kuroda   +12 more
doaj   +1 more source

Early predictors of separation anxiety disorder : early stranger anxiety, parental pathology and prenatal factors [PDF]

, 2011
<i>Objective:</i> The present study seeks to extend research on the etiology of separation anxiety disorder (SAD) in a German-speaking sample by examining differences between children with SAD and healthy comparisons, using a retrospective ...
Chantal Herren, Schneider, S., Kristen Lavallee, Carmen Adornetto, Blatter-Meunier, J., Adornetto, C., Judith Blatter-Meunier, Tina In-Albon, Herren, Chantal, Herren, C., Lavallee, Kristen, Blatter-Meunier, Judith, In-Albon, T., Schneider, Silvia, Silvia Schneider, Lavallee, K., Adornetto, Carmen, In-Albon, Tina   +17 more
core   +1 more source

Grandparent Prenatal Tobacco, Alcohol, Coffee, and Tea Consumption and Autism in the Third Generation

Autism Research, EarlyView.
ABSTRACT Exogenous prenatal exposures may affect neurodevelopment across multiple generations. We investigated grandmother and grandfather smoking, alcohol, coffee, and tea consumption during pregnancy in relation to their grandchildren's risk of autism spectrum disorder (ASD).
Michelle Pearl, Kimberly Berger, Piera M. Cirillo, Nickilou Y. Krigbaum, Victor Poon, Gayle C. Windham, Barbara A. Cohn   +6 more
wiley   +1 more source

When meta‐analyses mislead: Promises and pitfalls in teratology counselling

British Journal of Clinical Pharmacology, EarlyView.
Meta‐analysis has become a central tool for evidence synthesis in clinical teratology, offering the promise of increased statistical power, earlier signal detection and consolidated guidance for teratology counselling. When conducted rigorously and interpreted carefully, pooled analyses can provide clinicians with a structured basis for risk ...
Yusuf Cem Kaplan, Nusret Uysal
wiley   +1 more source