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Early Life Stress, Mood, and Anxiety Disorders

Chronic Stress, 2017
Early life stress has been shown to exert profound short- and long-term effects on human physiology both in the central nervous system and peripherally. Early life stress has demonstrated clear association with many psychiatric disorders including major ...
Shariful A. Syed, Charles B. Nemeroff
doaj   +2 more sources

Early life stress, HPA axis adaptation and mechanisms contributing to later health outcomes

Frontiers in Endocrinology, 2014
Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, which then modulates the degree of adaptation and response to a later stressor. It is known that early life stress can impact on later health but less is known about how early life stress ...
Jayanthi eManiam, Christopher eAntoniadis, Margaret eMorris   +2 more
doaj   +3 more sources

Early life stress impairs hippocampal subfield myelination [PDF]

Communications Biology
The hippocampus is an archicortical structure that is highly sensitive to experience and is made up of individual subfields. These subfields, crucial for learning and memory, rapidly develop and are vulnerable to early stress, yet the mechanisms are ...
Emily S. Nichols, Bradley G. Karat, Michael Grace, Samantha Bezanson, Ali R. Khan, Emma G. Duerden   +5 more
doaj   +2 more sources

Examining Social Touch in Early-Life Stress [PDF]

BJPsych Open
Aims Social contact is crucial for both immediate and later development of adaptive social and emotional behaviour. Tactile experiences during childhood influence the development of the social brain and frequent affectionate touch is associated with ...
Lena Lim
doaj   +2 more sources

Early-life stress sensitizes response to future stress: Evidence and mechanisms [PDF]

Neurobiology of Stress
Early-life stress sensitizes individuals to additional stressors and increases lifetime risk for mood and anxiety disorders. Research in both human populations and rodent models of early-life stress have sought to determine how different types of ...
Catherine Jensen Peña
doaj   +2 more sources

The evolving neurobiology of early-life stress. [PDF]

Neuron
Birnie MT, Baram TZ.
europepmc   +2 more sources

Early-life adversity and edentulism among Chinese older adults

BMC Oral Health, 2022
Background Emerging evidence indicate the relationship between ELA with oral health problems. However, most focus on single types of adversity. The association of cumulative ELA with edentulism, the final marker of disease burden for oral health, remains
Ziqing Tang, Chuanlong Huang, Yang Li, Ying Sun, Xin Chen   +4 more
doaj   +1 more source

Early Life Stress and Pediatric Posttraumatic Stress Disorder

Brain Sciences, 2020
Traumatic stress exposure during critical periods of development may have essential and long-lasting effects on the physical and mental health of individuals.
Panagiota Pervanidou, Gerasimos Makris, George Chrousos, Agorastos Agorastos   +3 more
doaj   +1 more source

Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation

Brain Sciences, 2023
Neonatal maternal separation (NMS) is an early-life stress (ELS) that can result in adult visceral hypersensitivity, which is usually manifested as chronic visceral pain.
Ziyang Chen, Tiantian Zhou, Yunfan Li, Tingting Li, Zhengnian Ding, Li Liu   +5 more
doaj   +1 more source

Ginseng total saponins rescue susceptibility to adult depression-like behaviors in mice induced by early-life stress via regulating CREB/BDNF/TrkB signaling

CyTA - Journal of Food, 2023
In this study, mice undergoing either short maternal separation (MS) or long MS during early postnatal life and then experiencing chronic unpredictable mild stress (CUMS) in adulthood were established to explore the critical mechanism of the ginseng ...
Yaoyao Bian, Lili Yang, Yutong Wang, Ping Lu, Wen Li, Jia Miao, Yiting Gong, Bin Zhang, Yanyun Yin   +8 more
doaj   +1 more source