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Temporal reorganization of maternal care during early life stress in mice [PDF]
Neurobiology of StressMaternal separation is a widely used early-life stress (ELS) paradigm in rodents. Disrupted maternal care by separation of pups from the dam for several hours per day across neonatal and juvenile development has been found to alter hypothalamic-pituitary-
Hannah Jo +2 more
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Early Life Stress, Mood, and Anxiety Disorders
Chronic Stress, 2017 Early life stress has been shown to exert profound short- and long-term effects on human physiology both in the central nervous system and peripherally. Early life stress has demonstrated clear association with many psychiatric disorders including major ...
Shariful A. Syed, Charles B. Nemeroff
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Early life stress impairs hippocampal subfield myelination [PDF]
Communications BiologyThe hippocampus is an archicortical structure that is highly sensitive to experience and is made up of individual subfields. These subfields, crucial for learning and memory, rapidly develop and are vulnerable to early stress, yet the mechanisms are ...
Emily S. Nichols +5 more
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Early-life stress sensitizes response to future stress: Evidence and mechanisms
Neurobiology of StressEarly-life stress sensitizes individuals to additional stressors and increases lifetime risk for mood and anxiety disorders. Research in both human populations and rodent models of early-life stress have sought to determine how different types of ...
Catherine Jensen Peña
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Early-life adversity and edentulism among Chinese older adults
BMC Oral Health, 2022 Background Emerging evidence indicate the relationship between ELA with oral health problems. However, most focus on single types of adversity. The association of cumulative ELA with edentulism, the final marker of disease burden for oral health, remains
Ziqing Tang +4 more
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Early Life Stress and Pediatric Posttraumatic Stress Disorder
Brain Sciences, 2020 Traumatic stress exposure during critical periods of development may have essential and long-lasting effects on the physical and mental health of individuals.
Panagiota Pervanidou +3 more
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Brain Sciences, 2023 Neonatal maternal separation (NMS) is an early-life stress (ELS) that can result in adult visceral hypersensitivity, which is usually manifested as chronic visceral pain.
Ziyang Chen +5 more
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CyTA - Journal of Food, 2023 In this study, mice undergoing either short maternal separation (MS) or long MS during early postnatal life and then experiencing chronic unpredictable mild stress (CUMS) in adulthood were established to explore the critical mechanism of the ginseng ...
Yaoyao Bian +8 more
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Frontiers in Cellular Neuroscience, 2022 Postnatal development of the brain is characterized by sensitive windows during which, local circuitry are drastically reshaped by life experiences. These critical periods (CPs) occur at different time points for different brain functions, presenting ...
Gabriele Chelini +3 more
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Early-Life Environment Influence on Late-Onset Alzheimer’s Disease
Frontiers in Cell and Developmental Biology, 2022 With the expand of the population’s average age, the incidence of neurodegenerative disorders has dramatically increased over the last decades. Alzheimer disease (AD) which is the most prevalent neurodegenerative disease is mostly sporadic and primarily ...
Thibaut Gauvrit +9 more
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