Results 21 to 30 of about 1,167,163 (294)

Early-Life Stress Induced by Neonatal Maternal Separation Leads to Intestinal 5-HT Accumulation and Causes Intestinal Dysfunction

Journal of Inflammation Research
Ding Yang,1 Rulan Bai,1 Chengzhong Li,2 Yan Sun,2 Hongyu Jing,1 Zixu Wang,1 Yaoxing Chen,1 Yulan Dong1 1College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of China; 2Department of Horticulture and Landscape ...
Yang D, Bai R, Li C, Sun Y, Jing H, Wang Z, Chen Y, Dong Y   +7 more
doaj   +2 more sources

Early life stress and psychopharmacology [PDF]

Psychopharmacology, 2011
The concept of early life stress (ELS) has long been a central focus in clinical psychiatry and psychology, owing in no small part to the primacy of this concept in psychoanalytic theory. Perhaps in response to that legacy, both clinical and preclinical biologically oriented researchers have become increasingly invested in understanding the adult ...
Lawrence H, Price, Thomas, Steckler
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Early-life stress and neurometabolites of the hippocampus [PDF]

Brain Research, 2010
We tested the hypothesis that early life stress would persistently compromise neuronal viability of the hippocampus of the grown nonhuman primate. Neuronal viability was assessed through ascertainment of N-acetyl aspartate (NAA)-an amino acid considered reflective of neuronal density/functional integrity-using in vivo proton magnetic resonance ...
Jeremy D, Coplan, Sanjay J, Mathew, Chadi G, Abdallah, Xiangling, Mao, John G, Kral, Eric L P, Smith, Leonard A, Rosenblum, Tarique D, Perera, Andrew J, Dwork, Patrick R, Hof, Jack M, Gorman, Dikoma C, Shungu   +11 more
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At the Crossroad Between Resiliency and Fragility: A Neurodevelopmental Perspective on Early-Life Experiences

Frontiers in Cellular Neuroscience, 2022
Postnatal development of the brain is characterized by sensitive windows during which, local circuitry are drastically reshaped by life experiences. These critical periods (CPs) occur at different time points for different brain functions, presenting ...
Gabriele Chelini, Luca Pangrazzi, Yuri Bozzi, Yuri Bozzi   +3 more
doaj   +1 more source

Telomeres and Early-Life Stress: An Overview [PDF]

Biological Psychiatry, 2013
The long-term sequelae of adverse early-life experiences have long been a focus in psychiatry, with a historic neurobiological emphasis on physiological systems that are demonstrably stress-responsive, such as the hypothalamic-pituitary-adrenal axis and neuroimmune function.
Lawrence H, Price, Hung-Teh, Kao, Darcy E, Burgers, Linda L, Carpenter, Audrey R, Tyrka   +4 more
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Early-Life Environment Influence on Late-Onset Alzheimer’s Disease

Frontiers in Cell and Developmental Biology, 2022
With the expand of the population’s average age, the incidence of neurodegenerative disorders has dramatically increased over the last decades. Alzheimer disease (AD) which is the most prevalent neurodegenerative disease is mostly sporadic and primarily ...
Thibaut Gauvrit, Thibaut Gauvrit, Hamza Benderradji, Hamza Benderradji, Luc Buée, Luc Buée, David Blum, David Blum, Didier Vieau, Didier Vieau   +9 more
doaj   +1 more source

Epigenetic Programming by Early-Life Stress [PDF]

, 2018
Studies show that adverse conditions during early life can increase risks of developing mood disorders later in life. It is currently hypothesized that levels of environmental adversity in this early developmental period are able to shape the experience-dependent maturation of stress-regulating pathways leading to long-lasting alterations in stress ...
Reema Abdulrahman S, Alyamani, Chris, Murgatroyd   +1 more
openaire   +2 more sources

The psychopathological potential of early life stress [PDF]

The World Journal of Biological Psychiatry, 2020
In the second decade of the twenty-first century, there has been an eruption of studies on the pathogenic role of stress in early life, named also ‘early life adversity’ or ‘childhood trauma’, in p...
openaire   +2 more sources

Parent-child interactions in early life mediating association between prenatal maternal stress and autistic-like behaviors among preschoolers

, 2023
A range of studies have shown that prenatal maternal stress (PNMS) exposure is associated with offspring autistic-like behaviors, however the potential pathways remain unexplored.
Wei-Qing Chen, Xiang-Yu Hou, Jing-Yi Chen, Sun, Deng-Li, Deng-Li Sun, Ying-Jie Chen, Chuan-an Wu, Yin, Xiao-Na, Yang, Gui-You, Hou, Xiang-Yu, Guo-Min Wen, Strodl, Esben, Li-Hua Huang, Chen, Wei-Qing, Gui-You Yang, Xian, Dan-Xia, Wu, Chuan-an, Wen, Guo-Min, Esben Strodl, Huang, Li-Hua, Xiao-Na Yin, Dan-Xia Xian, Chen, Jing-Yi, Chen, Ying-Jie   +23 more
core   +1 more source

The interplay of early-life stress, nutrition and immune activation programs adult hippocampal structure and function

Frontiers in Molecular Neuroscience, 2015
Early-life adversity increases the vulnerability to develop psychopathologies and cognitive decline later in life. This association is supported by clinical and preclinical studies.
Lianne eHoeijmakers, Paul eLucassen, Aniko eKorosi   +2 more
doaj   +1 more source