Results 41 to 50 of about 13,944,920 (244)

Examining Social Touch in Early-Life Stress

open access: yesBJPsych Open
Aims Social contact is crucial for both immediate and later development of adaptive social and emotional behaviour. Tactile experiences during childhood influence the development of the social brain and frequent affectionate touch is associated with ...
Lena Lim
doaj   +1 more source

MODELLING OF STRESS GRADIENT EFFECT ON FATIGUE LIFE USING WEIBULL BASED DISTRIBUTION FUNCTION [PDF]

open access: yes, 2013
In the present paper, a new approach is developed in order to take into account the stress gradient effect on fatigue life of structural components. The proposed approach is based on the weakest link concept in which the shape coefficient of the Weibull ...
PALIN-LUC, Thierry   +2 more
core  

Impact of Early Life Stress on Neurobiological Vulnerability to Obsessive-Compulsive Disorder: Early Life Stress & Neurobiological OCD Risk

open access: yesBrain Science Advances
The impact of early life stress on neurobiological vulnerability to obsessive-compulsive disorder (OCD) is a major focus of psychiatric research. Individuals with OCD frequently report that psychosocial stress exacerbates their symptoms, with many ...
Akshita Debnath, Souhrid Sarkar
doaj   +1 more source

Dysregulation of the mesoprefrontal dopamine circuit mediates an early-life stress-induced synaptic imbalance in the prefrontal cortex

open access: yesCell Reports, 2021
Summary: Stress adversely affects an array of cognitive functions. Although stress-related disorders are often addressed in adulthood, far less is known about how early-life stress (ELS) affects the developing brain in early postnatal periods.
Won Chan Oh   +7 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Effects of early-life environmental stress on risk-taking tendency of adolescents in rural areas of southwestern China

open access: yesFrontiers in Psychiatry
IntroductionAdolescence is a critical developmental phase characterized by increased risk-taking behaviors, which are not inherently maladaptive. According to life history theory, individuals raised in harsh and unpredictable environments are more likely
Jing Wu, Qiaobing Wu
doaj   +1 more source

Early Life Stress, Physiology, and Genetics: A Review

open access: yesFrontiers in Psychology, 2019
Early life stress (ELS) is a widely studied concept due to both its prevalent nature and its (presumed) detrimental consequences. In this review, we discuss the relationship between ELS and its underlying physiology spanning the sympathetic nervous ...
Nia Fogelman, Turhan Canli
doaj   +1 more source

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