Results 61 to 70 of about 13,944,920 (244)

Effects of Stress Early in Life on Drug Abuse at Adolescent Period in Rats [PDF]

, 2002
We have previously reported that stress early in life resulted in long-term behavioral and neurochemical alter-ations in later life. In this study, we aimed to examine the effect of stress early in life on drug abuse at adolescent period using ...
김동구
core  

Differential effects of two early life stress paradigms on cerebellar-dependent delay eyeblink conditioning

, 2020
Early life stress paradigms have become prominent in the animal literature to model atypical development. Currently, two models have prevailed within the literature: (1) limited bedding or nesting and (2) maternal separation or deprivation.
Hetrick, William P., Moussa-Tooks, Alexandra B., Green, John T.   +2 more
core   +1 more source

Early life stress and development: potential mechanisms for adverse outcomes

Journal of Neurodevelopmental Disorders, 2020
Background Chronic and/or extreme stress in early life, often referred to as early adversity, childhood trauma, or early life stress, has been associated with a wide range of adverse effects on development.
Karen E. Smith, Seth D. Pollak
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Role of stress and early-life stress in the pathogeny of inflammatory bowel disease

Frontiers in Neuroscience
Numerous preclinical and clinical studies have shown that stress is one of the main environmental factor playing a significant role in the pathogeny and life-course of bowel diseases.
Bruno Bonaz, Valérie Sinniger, Sonia Pellissier   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Exogenous determinants of early-life conditions, and mortality later in life [PDF]

We analyze causal effects of conditions early in life on the individual mortality rate later in life. Conditions early in life are captured by transitory features of the macro environment around birth, notably the state of the business cycle around birth,
Gabriele Doblhammer-Reiter, Kaare Christensen, Gerard J. van den Berg   +2 more
core  

Transgenerational Epigenetic Inheritance of Early-Life Stress from Grand-Dams Through Paternal Gametes: Impaired Social Cognition and Reduced Reactivity to Aversive Predictors in DAT-HET Rats

Biology
Transgenerational epigenetic inheritance has emerged as a compelling mechanism by which early-life stress can shape behavior in descendants with no direct exposure to trauma.
Eleonora D’Antonio, Gioia Zanfino, Concetto Puzzo, Micaela Capobianco, Francesco Mannella, Vincenzo De Laurenzi, Giuseppe Curcio, Walter Adriani   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Early and Later Life Stress Alter Brain Activity and Sleep in Rats [PDF]

, 2013
Exposure to early life stress may profoundly influence the developing brain in lasting ways. Neuropsychiatric disorders associated with early life adversity may involve neural changes reflected in EEG power as a measure of brain activity and disturbed ...
Bjørn Bjorvatn, Pallesen, Ståle, Robert Murison, Janne Grønli, Jellestad, Finn Konow, Anne Marita Milde, Murison, Robert, Grønli, Janne, Mrdalj, Jelena, Ståle Pallesen, Milde, Anne Marita, Reidun Ursin, Finn Konow Jellestad, Ursin, Reidun, Bjorvatn, Bjørn, Jelena Mrdalj   +15 more
core   +2 more sources