Results 81 to 90 of about 1,167,163 (294)
The long-term impact of adverse caregiving environments on epigenetic modifications and telomeres
Frontiers in Behavioral Neuroscience, 2015 Early childhood is a sensitive period in which infant-caregiver experiences have profound effects on brain development and behavior. Clinical studies have demonstrated that infants who experience stress and adversity in the context of caregiving are at ...
Jennifer eBlaze +2 more
doaj +1 more source
Early-Life Interpersonal and Affective Risk Factors for Pathological Gaming
Frontiers in Psychiatry, 2020 Internet gaming is among the most popular entertainment options, worldwide; however, a considerable proportion of gamers show symptoms of pathological gaming.
Silvia Bussone +4 more
doaj +1 more source
Exogenous determinants of early-life conditions, and mortality later in life [PDF]
We analyze causal effects of conditions early in life on the individual mortality rate later in life. Conditions early in life are captured by transitory features of the macro environment around birth, notably the state of the business cycle around birth,
Gabriele Doblhammer-Reiter +2 more
core
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Role of stress and early-life stress in the pathogeny of inflammatory bowel disease
Frontiers in NeuroscienceNumerous preclinical and clinical studies have shown that stress is one of the main environmental factor playing a significant role in the pathogeny and life-course of bowel diseases.
Bruno Bonaz +2 more
doaj +1 more source
Evo-devo of human adolescence: beyond disease models of early puberty [PDF]
, 2013 Despite substantial heritability in pubertal development, much variation remains to be explained, leaving room for the influence of environmental factors to adjust its phenotypic trajectory in the service of fitness goals.
Belsky, Jay +4 more
core +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
BiologyTransgenerational epigenetic inheritance has emerged as a compelling mechanism by which early-life stress can shape behavior in descendants with no direct exposure to trauma.
Eleonora D’Antonio +7 more
doaj +1 more source
Resistance to early-life stress in mice: effects of genetic background and stress duration
Frontiers in Behavioral Neuroscience, 2011 Early-life stress can induce marked behavioural and physiological impairments in adulthood including cognitive deficits, depression, anxiety and gastrointestinal dysfunction. Although robust rat models of early-life stress exist there are few established
Helene M. Savignac +4 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source