Results 91 to 100 of about 1,167,163 (294)
Frontiers in Behavioral Neuroscience, 2018 Exposure to adversity early in development alters brain and behavioral trajectories. Data continue to accumulate that epigenetic mechanisms are a mediating factor between early-life adversity and adult behavioral phenotypes.
Samantha M. Keller +2 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
European Journal of Psychotraumatology, 2012 Background : Childhood trauma is a major risk factor for the development of affective disorders later in life. We sought to determine whether this risk is linked to neurostructural changes in limbic brain regions after childhood trauma.
Claudia Buss +5 more
doaj +1 more source
Long-term effect of early-life stress from earthquake exposure on working memory in adulthood
, 2015 Na Li,1-3* Yumei Wang,1-3* Xiaochuan Zhao,1-3 Yuanyuan Gao,1-3 Mei Song,1-3 Lulu Yu,1-3 Lan Wang,1-3 Ning Li,1-3 Qianqian Chen,1-3 Yunpeng Li,1-3 Jiajia Cai,1-3 Xueyi Wang1-31Department of Psychiatry, The ...
Yu L +10 more
core
The maturation of reticulocytes. II. Life-span of red cells originating from stress reticulocytes
, 1975 Life-spans of macroreticuloytes and macrocytic red cells were studied. Rabbits were made anemic by injecting phenylhydrazine. Peripheral blood rich in reticulocytes was drawn, labeled with 3H-amino acids, and injected back into the anemic animal ...
Shimada, Atsuko
core +1 more source
New insights into early-life stress and behavioral outcomes [PDF]
, 2017 Adverse early-life experiences, including various forms of early-life stress, have consistently been linked with vulnerability to cognitive and emotional disorders later in life.
Ivy, Autumn +7 more
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Adverse effects of early-life stress: focus on the rodent neuroendocrine system
Neural Regeneration ResearchEarly-life stress is associated with a high prevalence of mental illnesses such as post-traumatic stress disorders, attention-deficit/hyperactivity disorder, schizophrenia, and anxiety or depressive behavior, which constitute major public health problems.
Seung Hyun Lee, Eui-Man Jung
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source