Results 91 to 100 of about 13,944,920 (244)

Early life origins of lung ageing : early life exposures and lung function decline in adulthood in two European cohorts aged 28-73 years [PDF]

, 2015
Early life environment is essential for lung growth and maximally attained lung function. Whether early life exposures impact on lung function decline in adulthood, an indicator of lung ageing, has scarcely been studied.; Spirometry data from two time ...
Svanes, C., Dratva, J., Norbäck D, Dan Norbäck (2143342), Villani, S., Gómez Real, Francisco, Dan Norbäck, Real, Francisco Gómez, Marco, Roberto de, Janson C, Dharmage, Shyamali C, Burdet, L., Jarvis, D, Villani S, de Marco, Roberto, Zemp, E., Accordini, Simone, Roberto de Marco, Julia Dratva, Elisabeth Zemp (142900), Accordini, S., Zemp, E, Deborah Jarvis (59834), Norbäck, D., Probst-Hensch, Nicole, Zemp, Elisabeth, Zemp, Elisabeth,, Probst-Hensch, N, Deborah Jarvis, Shyamali C. Dharmage (131486), Simona Villani, Pons, M, Joachim Heinrich (60421), Dharmage, S.C., Burdet, Luc, Luc Burdet (848789), Sunyer Deu, Jordi, Sunyer J, Accordini, Simone,, de Marco R, Dratva, Julia,, Jarvis, Deborah,, Simone Accordini (411992), Heinrich, Joachim,, Svanes, C, Marco Pons (848790), Dratva, J, Roberto de Marco (370210), Probst Hensch, Nicole, Christer Janson, Cecilie Svanes (59836), Thorarinn Gislason (508297), Heinrich, Joachim, Norbäck, Dan, Pons, M., Elisabeth Zemp, Heinrich, J., Julia Dratva (748527), Luc Burdet, Jarvis, Deborah, Villani, Simona, Nicole Probst-Hensch (520032), Real, FG, Jordi Sunyer, Dharmage SC, Villani, Simona,, Jarvis, D., de Marco, R., Dratva J, Accordini S, Pons M, Gislason, T., Probst-Hensch, N., Zemp E, Christer Janson (83414), Sunyer, J., Gislason, Thorarinn, Francisco Gómez Real (769225), Dharmage, Shyamali C.,, Real, Francisco Gomez,, Sunyer, Jordi,, Janson, Christer,, Sunyer, J, Janson, C., Thorarinn Gislason, Jarvis D, Svanes C, de Marco, Roberto,, Janson, C, Norback, D, Cecilie Svanes, Simona Villani (59831), de Marco, R, Burdet, Luc,, Pons, Marco,, Francisco Gómez Real, Real FG, Gislason, Thorarinn,, Shyamali C Dharmage, Norbäck, Dan,, Heinrich, J, Real, F.G., Simone Accordini, Joachim Heinrich, Janson, Christer, Dharmage, Shyamali C., Dratva, Julia, Jordi Sunyer (59833), Probst-Hensch N, Dharmage, SC, Pons, Marco, Sunyer, Jordi, Accordini, S, Gislason, T, Gislason T, Heinrich J, Svanes, Cecilie,, Villani, S, Probst-Hensch, Nicole,, Svanes, Cecilie, Nicole Probst-Hensch, Burdet, L, Marco Pons, Burdet L   +123 more
core   +2 more sources

Pharmacological Manipulation of DNA Methylation in Adult Female Rats Normalizes Behavioral Consequences of Early-Life Maltreatment

Frontiers in Behavioral Neuroscience, 2018
Exposure to adversity early in development alters brain and behavioral trajectories. Data continue to accumulate that epigenetic mechanisms are a mediating factor between early-life adversity and adult behavioral phenotypes.
Samantha M. Keller, Tiffany S. Doherty, Tania L. Roth   +2 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

EARLY-LIFE STRESS IMPAIRS STRESS-COPING STRATEGIES IN ADULT RATS

IBRO Neuroscience Reports, 2023
Jazmín Grillo Balboa, Ailen Colapietro, Verónica Cantarelli, Marina Ponzio, María Pallarés, Marta Antonelli   +5 more
doaj   +1 more source

Childhood adversity and psychopathology: the dimensions of timing, type and chronicity in a population-based sample of high-risk adolescents

Child and Adolescent Psychiatry and Mental Health
Background Research on childhood adversity and psychopathology has begun investigating the dimension of timing, however the results have been contradictory depending on the study population, outcome and how adverse life events (ALEs) were operationalized.
Milan Zarchev, Nina H. Grootendorst-van Mil, Diandra C. Bouter, Witte J. G. Hoogendijk, Cornelis L. Mulder, Astrid M. Kamperman   +5 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Neurobiology of early life stress: rodent studies

, 2002
It is now clear that early experience influences the long-term development of behavioral, neuroendocrine, and cognitive systems in a number of animal species.
Gutman, David A, Nemeroff, Charles B
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Insecure attachment during infancy predicts greater amygdala volumes in early adulthood [PDF]

, 2014
Background The quality of the early environment is hypothesized to be an influence on morphological development in key neural areas related to affective responding, but direct evidence to support this possibility is limited.
Pliatsikas, C., Johnstone, Tom, Halligan, S.L., Moutsiana, C., Goodyer, I., Goodyer, Ian, Moutsiana, Christina, Murray, Lynne, Halligan, Sarah L., Cooper, Peter J., Johnstone, T., Fearon, P., Cooper, P.J., Murray, L., Fearon, Pasco, Pliatsikas, Christos   +15 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source