Results 71 to 80 of about 13,944,920 (244)

Psychiatric and Functional Outcomes in Preterm School-Aged Children in Greece

Psychiatry International
Background: Preterm birth is a significant early-life stressor associated with increased psychiatric vulnerability and long-term functional impairments in school-aged children. Objective: To compare behavioral–emotional outcomes and functional competence
Symeon Dimitrios Daskalou, Theodoros N. Sergentanis, Nikolaos Gerosideris, Christina Ouzouni, Elpida Stratou, Ioanna Giannoula Katsouri   +5 more
doaj   +1 more source

Early life stress as an influence on limbic epilepsy: an hypothesis whose time has come?

Frontiers in Behavioral Neuroscience, 2009
The pathogenesis of mesial temporal lobe epilepsy (MTLE), the most prevalent form of refractory focal epilepsy in adults, is thought to begin in early life, even though seizures may not commence until adolescence or adulthood.
Amelia S Koe, Nigel C Jones, Michael R Salzberg   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Histological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male Rats

Journal of Mazandaran University of Medical Sciences, 2020
Background and purpose: Stressful events in early-life induce metabolic disorders in adolescence. The aim of this study was to investigate the effect of early-life stress on number or area of Langerhans islets in exposure to foot-shock and psychological ...
Homeira Zardooz, Forouzan Sadeghimahalli, Mina Salimi   +2 more
doaj  

Alteration of somatosensory response in adulthood by early life stress.

Frontiers in Molecular Neuroscience, 2015
Early-life stress is well known as a critical risk factor for mental and cognitive disorders in adulthood. Such disorders are accompanied by altered neuro- (synapto-) genesis and gene expression.
Yusuke eTakatsuru, Noriyuki eKoibuchi
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Larger amygdala volumes after childhood trauma associated with depression and cortisol response to psychosocial stress in adulthood

European Journal of Psychotraumatology, 2012
Background : Childhood trauma is a major risk factor for the development of affective disorders later in life. We sought to determine whether this risk is linked to neurostructural changes in limbic brain regions after childhood trauma.
Claudia Buss, Jens C. Pruessner, Helen Mayberg, Tanja Mletzko, Charles Nemeroff, Christine Heim   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Cortisol diurnal rhythm and stress reactivity in male adolescents with early-onset or adolescence-onset conduct disorder [PDF]

, 2008
Background: Previous studies have reported lower basal cortisol levels and reduced cortisol responses to stress in children and adolescents with conduct disorder (CD). It is not known whether these findings are specific to early-onset CD.
Stephanie H.M. van Goozen, Sarah J. Stollery, Gardiner, Julian, van Goozen, Stephanie HM, van Goozen, Stephanie H.M., Van Goozen, Stephanie Helena Maria, Graeme Fairchild, Stollery, Sarah J., Goodyer, Ian M, Herbert, Joe, Stollery, Sarah J, Brown, Jamie, Goodyer, Ian M., Goodyer, Ian M., Ian M. Goodyer, Julian Gardiner, Stollery, Sarah J.., Joe Herbert, Jamie Brown, Fairchild, Graeme   +19 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source