Results 101 to 110 of about 1,167,163 (294)

Early life stress and altered social behaviors: A perspective across species

Neuroscience Research
Childhood and adolescent affiliations guide how individuals engage in social relationships throughout their lifetime and adverse experiences can promote biological alterations that facilitate behavioral maladaptation.
Lyonna F. Parise, C. Joseph Burnett, Scott J. Russo   +2 more
doaj   +1 more source

Dynamic Effects of Early Adolescent Stress on Depressive-Like Behaviors and Expression of Cytokines and JMJD3 in the Prefrontal Cortex and Hippocampus of Rats

Frontiers in Psychiatry, 2018
Aims: Expression of inflammatory cytokines in the brain has been reported to be involved in the pathogenesis of and susceptibility to depression. Jumonji domain-containing 3 (Jmjd3), which is a histone H3 lysine 27 (H3K27) demethylase and can regulate ...
Rui Wang, Wei Wang, Jingjing Xu, Dexiang Liu, Hong Jiang, Fang Pan   +5 more
doaj   +1 more source

Cortisol reactivity to psychosocial stress is greater in sexual risk takers

, 2013
Several studies have reported an association between deviant behaviour and cortisol reactivity to stress. However relatively few studies have investigated the relationship between psychobiological stress reactivity and sexual risk taking behaviours.
Harrison, Claire, Melanie Mitchell, Michael A. Smith, Ratcliffe, Joanne, Mitchell, Melanie, Claire Harrison, Smith, Michael, Joanne M. Ratcliffe   +7 more
core   +1 more source

Cause-specific hospital admission and mortality among working men: association with socioeconomic circumstances in childhood and adult life, and the mediating role of daily stress [PDF]

, 2005
BACKGROUND: The aim of this study was to investigate the association of childhood and adulthood social class with the occurrence of specific diseases, including those not associated with a high mortality rate, and to investigate daily stress as the ...
Sterne, JAC, Macleod, J, Hart, CL, Macleod, John, Heslop, P., Metcalfe, C, MacLeod, J., Heslop, P, Davey Smith, G., Hart, C.L., Davey Smith, G, Metcalfe, C., Sterne, J.A.C.   +12 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Childhood adversity and psychopathology: the dimensions of timing, type and chronicity in a population-based sample of high-risk adolescents

Child and Adolescent Psychiatry and Mental Health
Background Research on childhood adversity and psychopathology has begun investigating the dimension of timing, however the results have been contradictory depending on the study population, outcome and how adverse life events (ALEs) were operationalized.
Milan Zarchev, Nina H. Grootendorst-van Mil, Diandra C. Bouter, Witte J. G. Hoogendijk, Cornelis L. Mulder, Astrid M. Kamperman   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Long-Lasting Sex-Specific Effects Based On Emotion- and Cognition-Related Behavioral Assessment of Adult Rats After Post-Traumatic Stress Disorder From Different Lengths of Maternal Separation

Frontiers in Psychiatry, 2019
Adverse early life stress is a major cause of vulnerability to various mental disorders in adulthood, including post-traumatic stress disorder (PTSD). Recent studies have suggested that early life stress can help the body adapt optimally when faced with ...
Rucui Yang, Haoran Sun, Yani Wu, Guohua Lu, Yanyu Wang, Qi Li, Jin Zhou, Hongwei Sun, Lin Sun   +8 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Acute early-life stress results in premature emergence of adult-like fear retention and extinction relapse in infant rats [PDF]

, 2019
Recent studies have shown that chronic early life stress results in precocious expression of the adult-like phenotype of fear retention and inhibition. However, it is unknown whether the experience of acute early trauma has the same effects as exposure ...
Richardson, Rick, Callaghan, Bridget L., Cowan, Caitlin S. M.   +2 more
core   +1 more source