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The (mathematical) modelling process in biosciences [PDF]

Frontiers in Genetics, 2015
In this communication we introduce a general framework and discussion on the role of models and the modelling process within the scientific activity in the biosciences realm.
Nestor V. Torres, Nestor V. Torres, Guido eSantos, Guido eSantos   +3 more
doaj   +3 more sources

Review of Mathematical Modelling Techniques with Applications in Biosciences

Iraqi Journal for Computer Science and Mathematics, 2022
Modelling can provide intellectual frameworks that are necessary to translate data into knowledge. Mathematical modelling has played an important role in many applications, such as ecology, genetics, engineering, psychology, sociology, physics and ...
ahmed hasan, Ahmed Sabah Al-Jilawi, Fouad H. Abd Alsharify   +2 more
doaj   +2 more sources

Directional alignment of different cell types organizes planar cell polarity [PDF]

iScience
Summary: Intercellular coupling between core PCP proteins is essential for unidirectional polarization of epithelial cells, known as planar cell polarity (PCP).
Masaki Arata, Hiroshi Koyama, Toshihiko Fujimori   +2 more
doaj   +2 more sources

Progress in the study of ion channel function, mechanisms, and mathematical modeling in Parkinson’s disease [PDF]

iScience
Summary: Parkinson’s disease is a progressive neurodegenerative disorder in which ion channel dysfunction significantly contributes to the pathophysiology.
Ruizhen Wang, Xuechun Zeng, Zhenqiang Zhang, Dongrui Ma   +3 more
doaj   +2 more sources

Systematic analysis and optimization of early warning signals for critical transitions using distribution data

iScience, 2023
Summary: Abrupt shifts between alternative regimes occur in complex systems, from cell regulation to brain functions to ecosystems. Several model-free early warning signals (EWS) have been proposed to detect impending transitions, but failure or poor ...
Daniele Proverbio, Alexander Skupin, Jorge Gonçalves   +2 more
doaj   +1 more source

Coordinated linear and rotational movements of endothelial cells compartmentalized by VE-cadherin drive angiogenic sprouting

iScience, 2023
Summary: Angiogenesis is a sequential process to extend new blood vessels from preexisting ones by sprouting and branching. During angiogenesis, endothelial cells (ECs) exhibit inhomogeneous multicellular behaviors referred to as “cell mixing,” in which ...
Kazuo Tonami, Tatsuya Hayashi, Yasunobu Uchijima, Masahiro Kanai, Fumitaka Yura, Jun Mada, Kei Sugahara, Yukiko Kurihara, Yuri Kominami, Toshiyuki Ushijima, Naoko Takubo, Xiaoxiao Liu, Hideto Tozawa, Yoshimitsu Kanai, Tetsuji Tokihiro, Hiroki Kurihara   +15 more
doaj   +1 more source

Immune response to SARS-CoV-2 in severe disease and long COVID-19

iScience, 2022
Summary: COVID-19 is mild to moderate in otherwise healthy individuals but may nonetheless cause life-threatening disease and/or a wide range of persistent symptoms.
Tomonari Sumi, Kouji Harada
doaj   +1 more source

Dynamically modeling the effective range of IL-2 dosage in the treatment of systemic lupus erythematosus

iScience, 2022
Summary: Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by an overactive immune response to self-antigen. The overactivation of CD4+ Foxp3− conventional T cells (Tcons) and the inactivation of CD4+ CD25+ Foxp3 ...
Xin Gao, Jing He, Xiaolin Sun, Fangting Li   +3 more
doaj   +1 more source

Bistable insulin response: The win-win solution for glycemic control

iScience, 2022
Summary: To satisfy both the safety and rapidity of glycemic control, muscles’ insulin response must be bistable, as theoretically predicted. Here, we test the bistability hypothesis by combining cellular experiments (to measure the threshold values in ...
Javed Akhtar, Yukun Han, Shangchen Han, Weiping Lin, Chenyu Cao, Ruowen Ge, Isaac Adeyemi Babarinde, Qingzhao Jia, Yueyang Yuan, Guangming Chen, Yajie Zhao, Richard Ye, Guozhen Liu, Luonan Chen, Guanyu Wang   +14 more
doaj   +1 more source

The nonequilibrium mechanism of noise-enhanced drug synergy in HIV latency reactivation

iScience, 2022
Summary: Noise-modulating chemicals can synergize with transcriptional activators in reactivating latent HIV to eliminate latent HIV reservoirs. To understand the underlying biomolecular mechanism, we investigate a previous two-gene-state model and ...
Xiaolu Guo, Tao Tang, Minxuan Duan, Lei Zhang, Hao Ge   +4 more
doaj   +1 more source