Results 11 to 20 of about 72,487 (242)
iScience, 2021 Summary: Bivalent chromatin is characterized by occupation of both activating and repressive histone modifications. Here, we develop a mathematical model that involves antagonistic histone modifications H3K4me3 and H3K27me3 to capture the key features of
Wei Zhao +4 more
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Mathematical modeling identifies LAG3 and HAVCR2 as biomarkers of T cell exhaustion in melanoma
iScience, 2023 Summary: Cytotoxic T lymphocytes (CTLs) control tumors via lysis of antigen-presenting targets or through secretion of cytokines such as interferon-γ (IFNG), which inhibit tumor cell proliferation.
Richard J. Beck +4 more
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iScience, 2021 Summary: The kidneys maintain homeostasis by controlling the amount of water and electrolytes in the blood. That function is accomplished by the nephrons, which transform glomerular filtrate into urine by a transport process mediated by membrane ...
Rui Hu +2 more
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Blood Flow Contributions to Cancer Metastasis
iScience, 2020 Summary: The distribution patterns of cancer metastasis depend on a sequence of steps involving adhesion molecules and on mechanical and geometrical effects related to blood circulation, but how much each of these two aspects contributes to the ...
Francesc Font-Clos +2 more
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Neural oscillations and speech processing at birth
iScience, 2023 Summary: Are neural oscillations biologically endowed building blocks of the neural architecture for speech processing from birth, or do they require experience to emerge?
Maria Clemencia Ortiz-Barajas +2 more
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iScience, 2023 Summary: Chemotherapy remains controversial for stage II nasopharyngeal carcinoma because of its considerable prognostic heterogeneity. We aimed to develop an MRI-based deep learning model for predicting distant metastasis and assessing chemotherapy ...
Yu-Jun Hu +15 more
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MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer
iScience, 2021 Summary: We hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of aneuploidy.
ManSai Acón +16 more
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Identifying stem cell numbers and functional heterogeneities during postembryonic organ growth
iScience, 2022 Summary: Uncovering the number of stem cells necessary for organ growth has been challenging in vertebrate systems. Here, we developed a mathematical model characterizing stem cells in the fish gill, an organ displaying non-exhaustive growth. We employ a
Diana-Patricia Danciu +3 more
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Reply to determining structural identifiability of parameter learning machines [PDF]
, 2016 The paper Ran and Hu (2014, Neurocomputing) examines identifiability and parameter redundancy in classes of models used in machine learning. This note discusses the results on global identifiability and also clarifies that the paper's results on ...
Cole, Diana J.
core +1 more source
A novel perturbation based compression complexity measure for networks
Heliyon, 2019 Measuring complexity of brain networks in the form of integrated information is a leading approach towards building a fundamental theory of consciousness.
Mohit Virmani, Nithin Nagaraj
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