Results 31 to 40 of about 1,696,822 (255)

How Retroactivity Affects the Behavior of Incoherent Feedforward Loops

iScience, 2020
Summary: An incoherent feedforward loop (IFFL) is a network motif known for its ability to accelerate responses and generate pulses. It remains an open question to understand the behavior of IFFLs in contexts with high levels of retroactivity, where an ...
Junmin Wang, Calin Belta, Samuel A. Isaacson   +2 more
doaj   +1 more source

Multistage feedback-driven compartmental dynamics of hematopoiesis

iScience, 2021
Summary: Human hematopoiesis is surprisingly resilient to disruptions, providing suitable responses to severe bleeding, long-lasting immune activation, and even bone marrow transplants.
Nathaniel Vincent Mon Père, Tom Lenaerts, Jorge Manuel dos Santos Pacheco, David Dingli   +3 more
doaj   +1 more source

Hydrogen peroxide induced cell death: One or two modes of action?

Heliyon, 2015
Imlay and Linn show that exposure of logarithmically growing Escherichia coli to hydrogen peroxide (H2O2) leads to two kinetically distinguishable modes of cell killing.
Lionel Uhl, Audrey Gerstel, Maialène Chabalier, Sam Dukan   +3 more
doaj   +1 more source

Excitable dynamics of flares and relapses in autoimmune diseases

iScience, 2023
Summary: Many autoimmune disorders exhibit flares in which symptoms erupt and then decline, as exemplified by multiple sclerosis (MS) in its relapsing-remitting form.
Yael Lebel, Tomer Milo, Alon Bar, Avi Mayo, Uri Alon   +4 more
doaj   +1 more source

Kansas City University of Medicine and Biosciences [PDF]

, 2023
This 2007 color postcard shows the front of the Administration Building of Kansas City University of Medicine and Biosciences. From 1917 to 1970 the building at 1750 Independence Avenue was occupied by Children’s Mercy Hospital.
Kansas City University of Medicine and Biosciences
core   +1 more source

A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer

iScience, 2020
Summary: Tumor heterogeneity and cisplatin resistance are major causes of tumor relapse and poor survival. Here, we show that in lung cancer, interaction between paxillin (PXN) and integrin β4 (ITGB4), components of the focal adhesion (FA) complex ...
Atish Mohanty, Arin Nam, Alex Pozhitkov, Lu Yang, Saumya Srivastava, Anusha Nathan, Xiwei Wu, Isa Mambetsariev, Michael Nelson, A.R. Subbalakshmi, Linlin Guo, Mohd W. Nasser, Surinder K. Batra, John Orban, Mohit Kumar Jolly, Erminia Massarelli, Prakash Kulkarni, Ravi Salgia   +17 more
doaj   +1 more source

IUPUI Center for Mathematical Biosciences [PDF]

, 2010
poster abstractAt-Large Mission: “to serve as an umbrella center for spearheading research and programmatic activities in the general bio-mathematics area” • promote and facilitate faculty excellence in mathematical and Computational research in the
Li, Fang, Ghosh, Samiran, Li, Jiliang, Worth, Robert, Zhu, Luoding, Chin, Ray, Rubchinsky, Leonid, Kuznetsov, Alexey, Boukai, Benzion, Rader, Andrew, Sarkar, Jyotirmoy, Fokin, Vladimir, Dziubek, Andrea, Guidoboni, Giovanna   +13 more
core   +1 more source

Age-structured models and optimal control in mathematical equidemiology: a survey [PDF]

, 2010
In this chapter we shall discuss the use of both optimal control theory and age-structured epidemic models in mathematical epidemiology. We use a very broad definition of optimal control, for example mathematical models for control by vaccination, as ...
Greenhalgh, David
core   +3 more sources

Blood flow regulation and oxygen transport in a heterogeneous model of the mouse retina [PDF]

, 2020
Elevated intraocular pressure is the primary risk factor for glaucoma, yet vascular health and ocular hemodynamics have also been established as important risk factors for the disease.
Siesky, Brent, Harris, Alon, Fry, Brendan C., Arciero, Julia   +3 more
core   +1 more source

Reversible adhesion by type IV pili leads to formation of permanent localized clusters

iScience, 2022
Summary: The formation of long-lived, multicellular clusters is a fundamental step in the physiopathology of many disease-causing bacteria. Experiments on abiotic surfaces suggest that bacterial colonization, including initial cluster formation, requires
María Victoria Pepe, Celeste Dea, Camila Genskowsky, Darío Capasso, Mara Sabrina Roset, Adriana Valeria Jäger, Fernando Peruani, Arlinet Kierbel   +7 more
doaj   +1 more source